Myosin-9 (MYH9) ELISA Kit for Human

This gene encodes a conventional non-muscle myosin; this protein should not be confused with the unconventional myosin-9a or 9b (MYO9A or MYO9B). The encoded protein is a myosin IIA heavy chain that contains an IQ domain and a myosin head-like domain which is involved in several important functions, including cytokinesis, cell motility and maintenance of cell shape. Defects in this gene have been associated with non-syndromic sensorineural deafness autosomal dominant type 17, Epstein syndrome, Alport syndrome with macrothrombocytopenia, Sebastian syndrome, Fechtner syndrome and macrothrombocytopenia with progressive sensorineural deafness. [provided by RefSeq, Dec 2011]

MYH9: Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Interacts with PDLIM2. Interacts with SLC6A4. Myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). Interacts with RASIP1. Interacts with DDR1. Interacts with SVIL and HTRA3. In the kidney, expressed in the glomeruli. Also expressed in leukocytes. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motor; Actin-binding; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 22q13.1

Cellular Component: actin cytoskeleton; actomyosin; brush border; cell-cell adherens junction; cleavage furrow; contractile ring; cytoplasm; cytosol; focal adhesion; immunological synapse; integrin complex; leading edge; membrane; myosin II complex; neuromuscular junction; nucleus; plasma membrane; protein complex; ruffle; signalosome; spindle; stress fiber; uropod

Molecular Function: actin binding; actin filament binding; actin-dependent ATPase activity; ADP binding; ATP binding; ATPase activity; calmodulin binding; microfilament motor activity; motor activity; protein anchor; protein binding; protein domain specific binding; protein homodimerization activity

Biological Process: actin cytoskeleton reorganization; actin filament-based movement; actomyosin structure organization and biogenesis; angiogenesis; axon guidance; blood vessel endothelial cell migration; cytokinesis; ephrin receptor signaling pathway; establishment of meiotic spindle localization; establishment of T cell polarity; in utero embryonic development; integrin-mediated signaling pathway; leukocyte migration; meiotic spindle organization and biogenesis; membrane protein ectodomain proteolysis; monocyte differentiation; myoblast fusion; phagocytosis, engulfment; platelet formation; protein transport; regulation of cell shape; small GTPase mediated signal transduction; uropod organization and biogenesis

Disease: Deafness, Autosomal Dominant 17; Epstein Syndrome; Fechtner Syndrome; Macrothrombocytopenia And Progressive Sensorineural Deafness; May-hegglin Anomaly; Sebastian Syndrome