Asialoglycoprotein Receptor 1 (ASGR1) ELISA Kit for Mouse

Name: Mouse ASGR1 ELISA Kit; Asialoglycoprotein Receptor 1; MyBioSource
Brand: MyBioSource
SKU: MBS762285
Price: 405 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS762285

Principle of the Assay: This kit was based on sandwich enzyme-linked immune-sorbent assay technology. Capture antibody was pre-coated onto 96-well plates. And the biotin conjugated antibody was used as detection antibodies. The standards, test samples and… More details

$405 / 48-Strip-Wells +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

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Product Overview

Online Datasheet in PDF

Product Name

Asialoglycoprotein Receptor 1 (ASGR1), ELISA Kit

Full Product Name

Mouse Asialoglycoprotein Receptor 1 ELISA Kit

Product Gene Name

ASGR1 elisa kit

Product Synonym Names

ASGR1/ASGPR1/CLEC4H1/MHL1/RHL1/ASGPR/ASGPR 1/ASGP-R 1/asialoglycoprotein receptor 1/CLEC4H1ASGPR1/C-type lectin domain family 4 member H1/Hepatic lectin H1/HL-1

Species Reactivity

Mouse

Assay Type

Sandwich

Samples

Serum, plasma, tissue homogenates and other biological fluids

Detection Range

31.25-2000pg/ml

Sensitivity

18.75pg/ml

Specificity

This assay has high sensitivity and excellent specificity for detection of ASGR1. No significant cross-reactivity or interference between ASGR1 and analogues was observed.

Preparation and Storage

Store entire kit at 2-8C for short-term. For longer-term, please store the microplate & standard at -20C, while the remaining reagents can be stored at 2-8C

Inter-assay Precision

CV<10%

Intra-assay Precision

CV<8%

Molecular Weight

29,144 Da

OMIM

108360

ISO Certification

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Other Notes

Small volumes of ASGR1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ASGR1 purchase

MBS762285 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Asialoglycoprotein Receptor 1 (ASGR1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing ASGR1. The ELISA analytical biochemical technique of the MBS762285 kit is based on ASGR1 antibody-ASGR1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ASGR1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ASGR1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for ASGR1. It may not necessarily be applicable to this product.

NCBI GI #

18149183

NCBI GeneID

432

NCBI Accession #

BAB83508.1

UniProt Secondary Accession #

I3L1X1

UniProt Related Accession #

P07306

NCBI Official Full Name

Asialoglycoprotein receptor 1

NCBI Official Synonym Full Names

asialoglycoprotein receptor 1

NCBI Official Symbol

ASGR1

NCBI Official Synonym Symbols

HL-1; ASGPR; ASGPR1; CLEC4H1

UniProt Protein Name

Asialoglycoprotein receptor 1

UniProt Synonym Protein Names

C-type lectin domain family 4 member H1; Hepatic lectin H1; HL-1

Protein Family

Asialoglycoprotein receptor

UniProt Gene Name

ASGR1

UniProt Synonym Gene Names

CLEC4H1; ASGP-R 1; ASGPR 1; HL-1

UniProt Entry Name

ASGR1_HUMAN

NCBI Protein Information

asialoglycoprotein receptor 1

NCBI Summary for ASGR1

This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the more abundant major subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

UniProt Comments for ASGR1

ASGR1: Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 17p13.2

Cellular Component: extracellular region; integral to plasma membrane

Molecular Function: asialoglycoprotein receptor activity; carbohydrate binding; metal ion binding; protein binding; protein homodimerization activity

Biological Process: cellular response to extracellular stimulus; receptor-mediated endocytosis

Research Articles on ASGR1

1. Anti-ASGPR antibody could be used for specific and efficient HCC CTC enrichment, and anti-P-CK combined with anti-CPS1 antibodies is superior to identification with one antibody alone in the sensitivity for HCC CTC detection.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with ASGR1 elisa kit

Reference Product	PubMed Publications
ST3GAL4 elisa kit	>1 publications with ASGR1 and ST3GAL4

Pathways associated with ASGR1 elisa kit

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Thyroid Hormone Synthesis Pathway antibodies	Thyroid Hormone Synthesis Pathway Diagram
Thyroid Hormone Synthesis Pathway antibodies	Thyroid Hormone Synthesis Pathway Diagram

Diseases associated with ASGR1 elisa kit

Disease Name	Pubmed Publications
Liver Diseases Antibodies	>3 publications with ASGR1 and Liver Diseases
Carcinoma, Hepatocellular Antibodies	>2 publications with ASGR1 and Carcinoma, Hepatocellular
Congenital Abnormalities Antibodies	>1 publications with ASGR1 and Congenital Abnormalities
Disease Models, Animal Antibodies	>1 publications with ASGR1 and Disease Models, Animal
Cardiovascular Diseases Antibodies	>1 publications with ASGR1 and Cardiovascular Diseases
Fibrosis Antibodies	>1 publications with ASGR1 and Fibrosis
Inflammation Antibodies	>1 publications with ASGR1 and Inflammation
Liver Neoplasms Antibodies	>1 publications with ASGR1 and Liver Neoplasms

Organs/Tissues associated with ASGR1 elisa kit

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>17 publications with ASGR1 and Liver
Muscle Antibodies	>1 publications with ASGR1 and Muscle
Embryonic Tissue Antibodies	>1 publications with ASGR1 and Embryonic Tissue
Skin Antibodies	>1 publications with ASGR1 and Skin
Testis Antibodies	>1 publications with ASGR1 and Testis