Hepatocyte Nuclear Factor 4 Alpha (HNF4a) ELISA Kit for Mouse

HNF4 alpha: a nuclear transcription factor which binds DNA as a homodimer. Controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic gene, alpha 1-antitrypsin, apolipoprotein CIII, and transthyretin genes. May be essential for development of the liver, kidney and intestine. Mutations have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Four alternatively spliced isoforms have been described.

Protein type: DNA-binding; Nuclear receptor; Transcription factor

Cellular Component: cytoplasm; nucleus; transcription factor complex

Molecular Function: acyl-CoA binding; DNA binding; fatty acid binding; palmitoyl-CoA hydrolase activity; protein binding; protein homodimerization activity; receptor binding; RNA polymerase II transcription factor activity, enhancer binding; sequence-specific DNA binding; steroid hormone receptor activity; transcription factor activity; transcription factor binding

Biological Process: acyl-CoA metabolic process; aging; blood coagulation; cell differentiation; establishment of tissue polarity; glucose homeostasis; intercellular junction assembly and maintenance; lipid homeostasis; lipid metabolic process; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of mitotic cell cycle; negative regulation of protein import into nucleus, translocation; negative regulation of transcription factor activity; negative regulation of tyrosine phosphorylation of Stat5 protein; ornithine metabolic process; phospholipid homeostasis; positive regulation of fatty acid biosynthetic process; positive regulation of gluconeogenesis; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of gastrulation; regulation of insulin secretion; regulation of lipid metabolic process; regulation of microvillus biogenesis; regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; response to cAMP; response to drug; response to glucose stimulus; sex differentiation; xenobiotic metabolic process