Estrogen Receptor Beta (ERbeta) ELISA Kit for Human

ER-beta: a nuclear hormone receptor and transcription factor. Binds and activated by estrogen. Regulates gene expression and affects cellular proliferation and differentiation in target tissues. Binds estrogens with an affinity similar to that of ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Eight alternatively-spliced isoforms have been described. Isoform beta-cx lacks ligand binding ability and has no or only very low ERE binding activity resulting in the loss of ligand-dependent transactivation ability.

Protein type: DNA-binding; Nuclear receptor

Cellular Component: cell soma; cilium; cytoplasm; mitochondrion; neuron projection; nucleus; perikaryon; perinuclear region of cytoplasm; plasma membrane

Molecular Function: DNA binding; drug binding; enzyme binding; estrogen receptor activity; estrogen response element binding; hormone binding; lipid binding; metal ion binding; peroxisome proliferator activated receptor binding; protein binding; sequence-specific DNA binding; steroid binding; steroid hormone receptor activity; transcription factor activity; zinc ion binding

Biological Process: behavioral fear response; brain development; estrogen receptor signaling pathway; induction of apoptosis by hormones; learning and/or memory; negative regulation of behavior; negative regulation of cell proliferation; negative regulation of epithelial cell proliferation; negative regulation of smooth muscle cell proliferation; negative regulation of transcription from RNA polymerase II promoter; neuron migration; ovarian follicle development; positive regulation of apoptosis; positive regulation of epidermal growth factor receptor signaling pathway; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of vasodilation; regulation of cell proliferation; regulation of neuron apoptosis; regulation of transcription, DNA-dependent; response to testosterone stimulus; Sertoli cell proliferation; steroid hormone mediated signaling; steroid hormone receptor signaling pathway; transcription from RNA polymerase II promoter; transcription, DNA-dependent; uterus development; vagina development