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Interferon Alpha/Beta Receptor 1 (IFNAR1) ELISA Kit for Human

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS762571

Principle of the Assay||This kit was based on sandwich enzyme-linked immune-sorbent assay technology. Anti-Human IFNAR1/Interferon alpha antibody was pre-coated onto 96-well plates. And the biotin conjugated anti-Human IFNAR1/Interferon alpha antibody was… More details

$405 / 48-Strip-Wells +1 FREE 8GB USB

Product Documentation

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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Interferon alpha/beta receptor 1 (IFNAR1), ELISA Kit
Full Product Name
Human Interferon alpha/beta receptor 1 ELISA Kit
Product Gene Name
IFNAR1 elisa kit
Product Synonym Names
IFNAR1/Interferon alpha/beta receptor 1/IFN-R-1/IFN-alpha/beta receptor 1/Type I interferon receptor 1/Cytokine receptor class-II member 1/Cytokine receptor family 2 member 1/CRF2-1/IFNAR/alpha-type antiviral protein/AVP/beta-type antiviral protein/CRF2-1/human interferon-alpha receptor (HuIFN-alpha-Rec)10IFRC/IFNBR/interferon (alpha; beta and omega) receptor 1/interferon-alpha/beta receptor alpha chain
Species Reactivity
Human
Assay Type
Sandwich ELISA, Double Antibody
Samples
Serum, Plasma, Cell Culture Supernatant, cell or tissue lysate, Other liquid samples
Detection Range
0.156-10ng/ml
Sensitivity
0.094ng/ml
Preparation and Storage
Store entire kit at 2-8C for short-term. For longer-term, please store the microplate & standard at -20C, while the remaining reagents can be stored at 2-8C
Molecular Weight
56,046 Da
OMIM
107450
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Typical Testing Data of IFNAR1 elisa kit

Human IFNAR1 ELISA Kit – Cat# MBS762571

Typical Standard Curve of IFNAR1 elisa kit

Human IFNAR1 ELISA Kit, Typical Standard Curve – Cat# MBS762571

Other Notes

Small volumes of IFNAR1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IFNAR1 purchase

MBS762571 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Interferon alpha/beta receptor 1 (IFNAR1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing IFNAR1. The ELISA analytical biochemical technique of the MBS762571 kit is based on IFNAR1 antibody-IFNAR1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect IFNAR1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, IFNAR1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for IFNAR1. It may not necessarily be applicable to this product.

NCBI GI #
46488932
NCBI GeneID
3454
NCBI Accession #
NP_000620.2
UniProt Secondary Accession #
Q53GW9; Q53H11; Q6PKD7; Q7M4L2; Q8WTZ2; B2R6L9; B4DNT3; D3DSF0
UniProt Related Accession #
P17181
GenBank Nucleotide #
NM_000629.2
NCBI Official Full Name
interferon alpha/beta receptor 1
NCBI Official Synonym Full Names
interferon alpha and beta receptor subunit 1
NCBI Official Symbol
IFNAR1
NCBI Official Synonym Symbols
AVP; IFRC; IFNAR; IFNBR; IFN-alpha-REC
UniProt Protein Name
Interferon alpha/beta receptor 1
UniProt Synonym Protein Names
Cytokine receptor class-II member 1; Cytokine receptor family 2 member 1; CRF2-1; Type I interferon receptor 1
Protein Family
Interferon alpha/beta receptor
UniProt Gene Name
IFNAR1
UniProt Synonym Gene Names
IFNAR; IFN-R-1; IFN-alpha/beta receptor 1; CRF2-1
UniProt Entry Name
INAR1_HUMAN
NCBI Protein Information
interferon alpha/beta receptor 1

NCBI Summary for IFNAR1

The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. [provided by RefSeq, Jul 2008]
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UniProt Comments for IFNAR1

IFNAR1: receptor for interferons alpha and beta. Belongs to the type II cytokine family of receptors. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves. Tyk2 tyrosine kinase is essential for stable cell surface expression of IFNAR1. Present in all tissues and even on the surface of most IFN-resistant cells.

Protein type: Receptor, cytokine; Membrane protein, integral

Chromosomal Location of Human Ortholog: 21q22.11

Cellular Component: integral to plasma membrane; intracellular; plasma membrane

Molecular Function: interferon-alpha/beta binding; interferon-alpha/beta receptor activity; protein binding

Biological Process: cytokine and chemokine mediated signaling pathway; defense response to virus; interferon type I biosynthetic process; JAK-STAT cascade; positive regulation of interferon-beta production; positive regulation of interferon-gamma production; positive regulation of interleukin-1 beta secretion; positive regulation of transcription, DNA-dependent; regulation of peptidyl-tyrosine phosphorylation; response to lipopolysaccharide; response to virus; T cell activation
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Research Articles on IFNAR1

1. IFNL4 and IFNL3 associated polymorphisms strongly influence the spontaneous IFN-alpha receptor-1 expression in HCV-infected patients

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with IFNAR1 elisa kit

 Reference Product  PubMed Publications
 IFNAR2 elisa kit  >171 publications with IFNAR1 and IFNAR2
 TYK2 elisa kit  >59 publications with IFNAR1 and TYK2
 STAT2 elisa kit  >58 publications with IFNAR1 and STAT2
 JAK1 elisa kit  >39 publications with IFNAR1 and JAK1
 SOCS1 elisa kit  >15 publications with IFNAR1 and SOCS1
 IFNB1 elisa kit  >6 publications with IFNAR1 and IFNB1
 IFNA1 elisa kit  >4 publications with IFNAR1 and IFNA1
 IFNA2 elisa kit  >2 publications with IFNAR1 and IFNA2

Pathways associated with IFNAR1 elisa kit

 Products by Pathway  Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Downstream Signaling In Naive CD8+ T Cells Pathway antibodies  Downstream Signaling In Naive CD8+ T Cells Pathway Diagram
 Hepatitis B Pathway antibodies  Hepatitis B Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram

Diseases associated with IFNAR1 elisa kit

 Disease Name  Pubmed Publications
 Virus Diseases Antibodies  >130 publications with IFNAR1 and Virus Diseases
 Inflammation Antibodies  >77 publications with IFNAR1 and Inflammation
 Liver Diseases Antibodies  >57 publications with IFNAR1 and Liver Diseases
 Necrosis Antibodies  >30 publications with IFNAR1 and Necrosis
 Fever Antibodies  >11 publications with IFNAR1 and Fever
 Cardiovascular Diseases Antibodies  >11 publications with IFNAR1 and Cardiovascular Diseases
 Heart Diseases Antibodies  >10 publications with IFNAR1 and Heart Diseases
 Down Syndrome Antibodies  >7 publications with IFNAR1 and Down Syndrome
 Kidney Diseases Antibodies  >5 publications with IFNAR1 and Kidney Diseases
 Lung Neoplasms Antibodies  >5 publications with IFNAR1 and Lung Neoplasms

Organs/Tissues associated with IFNAR1 elisa kit

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >155 publications with IFNAR1 and Blood
 Liver Antibodies  >57 publications with IFNAR1 and Liver
 Bone Antibodies  >49 publications with IFNAR1 and Bone
 Bone Marrow Antibodies  >46 publications with IFNAR1 and Bone Marrow
 Lung Antibodies  >42 publications with IFNAR1 and Lung
 Spleen Antibodies  >28 publications with IFNAR1 and Spleen
 Brain Antibodies  >27 publications with IFNAR1 and Brain
 Skin Antibodies  >13 publications with IFNAR1 and Skin
 Lymph Node Antibodies  >13 publications with IFNAR1 and Lymph Node
 Lymph Antibodies  >13 publications with IFNAR1 and Lymph
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