Hepatic Triacylglycerol Lipase (LIPC) ELISA Kit for Human

LIPC: Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin. Defects in LIPC are the cause of hepatic lipase deficiency (HL deficiency). A disorder characterized by elevated levels of beta-migrating very low density lipoproteins, and abnormally triglyceride-rich low and high density lipoproteins. Belongs to the AB hydrolase superfamily. Lipase family.

Protein type: Secreted, signal peptide; EC 3.1.1.3; Secreted; Lipid Metabolism - glycerolipid; Phospholipase

Cellular Component: cell surface; early endosome; extracellular region; extracellular space; late endosome; microvillus

Molecular Function: acylglycerol lipase activity; apolipoprotein binding; heparan sulfate proteoglycan binding; heparin binding; hydrolase activity; lipase activity; lipid binding; low-density lipoprotein binding; lysophospholipase activity; phospholipase A1 activity; protein binding; transferase activity, transferring acyl groups; triacylglycerol lipase activity

Biological Process: cholesterol homeostasis; cholesterol metabolic process; cholesterol transport; fatty acid biosynthetic process; fatty acid metabolic process; glycerophospholipid catabolic process; heparan sulfate proteoglycan biosynthetic process; lipid catabolic process; lipid metabolic process; neutral lipid catabolic process; phosphatidic acid metabolic process; phosphatidylcholine metabolic process; phosphatidylethanolamine metabolic process; phosphatidylserine metabolic process; protein oligomerization; triacylglycerol catabolic process; triacylglycerol metabolic process