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Nuclear Receptor Corepressor 1 (NCOR1) ELISA Kit for Human

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS762786

Principle of the Assay||This kit was based on sandwich enzyme-linked immune-sorbent assay technology. Anti-Human NCOR1 antibody was pre-coated onto 96-well plates. And the biotin conjugated anti-Human NCOR1 antibody was used as detection antibodies. The… More details

$405 / 48-Strip-Wells +1 FREE 8GB USB

Product Documentation

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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Nuclear receptor corepressor 1 (NCOR1), ELISA Kit
Full Product Name
Human Nuclear receptor corepressor 1 ELISA Kit
Product Gene Name
NCOR1 elisa kit
Product Synonym Names
NCOR1/N-CoR/N-CoR1/TRAC1/hN-CoR/nuclear receptor corepressor 1/nuclear receptor co-repressor 1
Species Reactivity
Human
Assay Type
Sandwich ELISA, Double Antibody
Samples
Serum, Plasma, Cell Culture Supernatant, cell or tissue lysate, Other liquid samples
Detection Range
15.625-1000pg/ml
Sensitivity
9.375pg/ml
Preparation and Storage
Store entire kit at 2-8C for short-term. For longer-term, please store the microplate & standard at -20C, while the remaining reagents can be stored at 2-8C
Molecular Weight
266,519 Da
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Typical Testing Data of NCOR1 elisa kit

Human NCOR1 ELISA Kit – Cat# MBS762786

Typical Standard Curve of NCOR1 elisa kit

Human NCOR1 ELISA Kit, Typical Standard Curve – Cat# MBS762786

Other Notes

Small volumes of NCOR1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NCOR1 purchase

MBS762786 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Nuclear receptor corepressor 1 (NCOR1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing NCOR1. The ELISA analytical biochemical technique of the MBS762786 kit is based on NCOR1 antibody-NCOR1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect NCOR1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, NCOR1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for NCOR1. It may not necessarily be applicable to this product.

NCBI GI #
356640155
NCBI GeneID
20185
NCBI Accession #
NP_001239242.1
UniProt Secondary Accession #
Q60812
UniProt Related Accession #
Q60974
GenBank Nucleotide #
NM_001252313.1
NCBI Official Full Name
nuclear receptor corepressor 1 isoform 1
NCBI Official Synonym Full Names
nuclear receptor co-repressor 1
NCBI Official Symbol
Ncor1
NCBI Official Synonym Symbols
N-CoR; RIP13; Rxrip13; mKIAA1047; 5730405M06Rik; A230020K14Rik
UniProt Protein Name
Nuclear receptor corepressor 1
UniProt Synonym Protein Names
Retinoid X receptor-interacting protein 13; RIP13
Protein Family
Nuclear receptor corepressor
UniProt Gene Name
Ncor1
UniProt Synonym Gene Names
Rxrip13; N-CoR; N-CoR1; RIP13
UniProt Entry Name
NCOR1_MOUSE
NCBI Protein Information
nuclear receptor corepressor 1

UniProt Comments for NCOR1

N-CoR1: is a protein that regulates the activity of some transcription factors, including nuclear receptors, by promoting histone deacetylation and chromatin condensation, thereby altering the accessibility of various genes to the transcriptional machinery. Is known to play a role genetic programming including that for myogenesis. Is a component of a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex associates with the thyroid and the retinoic acid receptors in the absence of ligand. Interacts with the catalytic domain of HDAC9. Increased expression correlates with the loss of vitamin D responsiveness in aggressive androgen-independent prostate cancer cells. Its gene tends to be overexpressed in multiple-myeloma cell lines.

Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor

Cellular Component: cytoplasm; histone deacetylase complex; membrane; nuclear chromatin; nucleus; perinuclear region of cytoplasm; Sin3 complex; spindle microtubule; transcription factor complex; transcriptional repressor complex

Molecular Function: chromatin binding; DNA binding; estrogen receptor binding; histone deacetylase binding; histone deacetylase regulator activity; ligand-dependent nuclear receptor binding; nuclear hormone receptor binding; peroxisome proliferator activated receptor binding; protein binding; protein domain specific binding; retinoic acid receptor binding; retinoid X receptor binding; sequence-specific DNA binding; thyroid hormone receptor binding; transcription corepressor activity; transcription factor activity

Biological Process: CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation; cholesterol homeostasis; circadian regulation of gene expression; negative regulation of JNK cascade; negative regulation of phosphoinositide 3-kinase cascade; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of cell proliferation; positive regulation of histone deacetylation; regulation of multicellular organism growth; regulation of transcription from RNA polymerase II promoter; spindle assembly; thalamus development
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Research Articles on NCOR1

1. Phosphorylation-mediated recruitment switch of NCoR1 between nuclear receptor subsets provides a mechanism by which corepressors can selectively modulate liver energy metabolism during the fasting-feeding transition

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with NCOR1 elisa kit

 Reference Product  PubMed Publications
 Hdac3 elisa kit  >47 publications with NCOR1 and Hdac3
 Hdac1 elisa kit  >28 publications with NCOR1 and Hdac1
 Ncoa2 elisa kit  >18 publications with NCOR1 and Ncoa2
 Sin3a elisa kit  >17 publications with NCOR1 and Sin3a
 Ncoa3 elisa kit  >11 publications with NCOR1 and Ncoa3
 Hdac5 elisa kit  >5 publications with NCOR1 and Hdac5
 Thrb elisa kit  >2 publications with NCOR1 and Thrb

Pathways associated with NCOR1 elisa kit

 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Bmal1:Clock,Npas2 Activates Circadian Gene Expression Pathway antibodies  Bmal1:Clock,Npas2 Activates Circadian Gene Expression Pathway Diagram
 Circadian Clock Pathway antibodies  Circadian Clock Pathway Diagram
 Delta-Notch Signaling Pathway antibodies  Delta-Notch Signaling Pathway Diagram
 Downregulation Of SMAD2/3:SMAD4 Transcriptional Activity Pathway antibodies  Downregulation Of SMAD2/3:SMAD4 Transcriptional Activity Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram

Organs/Tissues associated with NCOR1 elisa kit

 Organ/Tissue Name  Pubmed Publications
 Thyroid Antibodies  >145 publications with NCOR1 and Thyroid
 Blood Antibodies  >40 publications with NCOR1 and Blood
 Liver Antibodies  >37 publications with NCOR1 and Liver
 Brain Antibodies  >36 publications with NCOR1 and Brain
 Prostate Antibodies  >24 publications with NCOR1 and Prostate
 Muscle Antibodies  >16 publications with NCOR1 and Muscle
 Kidney Antibodies  >15 publications with NCOR1 and Kidney
 Bone Antibodies  >13 publications with NCOR1 and Bone
 Pituitary Gland Antibodies  >12 publications with NCOR1 and Pituitary Gland
 Embryonic Tissue Antibodies  >9 publications with NCOR1 and Embryonic Tissue
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