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Molybdenum Cofactor Sulfurase (MOCOS) ELISA Kit for Human

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS762793

Principle of the Assay||This kit was based on sandwich enzyme-linked immune-sorbent assay technology. Anti-Human MOCOS antibody was pre-coated onto 96-well plates. And the biotin conjugated anti-Human MOCOS antibody was used as detection antibodies. The… More details

$405 / 48-Strip-Wells +1 FREE 8GB USB

Product Documentation

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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Molybdenum cofactor sulfurase (MOCOS), ELISA Kit
Full Product Name
Human Molybdenum cofactor sulfurase ELISA Kit
Product Gene Name
MOCOS elisa kit
Product Synonym Names
MOCOS/Molybdenum cofactor sulfurase/MCS/MOS/MoCo sulfurase/hMCS/Molybdenum cofactor sulfurtransferase
Species Reactivity
Human
Assay Type
Sandwich ELISA, Double Antibody
Samples
Serum, Plasma, Cell Culture Supernatant, cell or tissue lysate, Other liquid samples
Detection Range
0.313-20ng/ml
Sensitivity
0.188ng/ml
Preparation and Storage
Store entire kit at 2-8C for short-term. For longer-term, please store the microplate & standard at -20C, while the remaining reagents can be stored at 2-8C
Molecular Weight
98,120 Da
OMIM
603592
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Typical Testing Data of MOCOS elisa kit

Human MOCOS ELISA Kit – Cat# MBS762793

Typical Standard Curve of MOCOS elisa kit

Human MOCOS ELISA Kit, Typical Standard Curve – Cat# MBS762793

Other Notes

Small volumes of MOCOS elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MOCOS purchase

MBS762793 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Molybdenum cofactor sulfurase (MOCOS) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing MOCOS. The ELISA analytical biochemical technique of the MBS762793 kit is based on MOCOS antibody-MOCOS antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect MOCOS antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, MOCOS. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for MOCOS. It may not necessarily be applicable to this product.

NCBI GI #
157388923
NCBI GeneID
55034
NCBI Accession #
NP_060417.2
UniProt Secondary Accession #
Q53GP5; Q8N3A4; Q9NWM7
UniProt Related Accession #
Q96EN8
GenBank Nucleotide #
NM_017947.2
NCBI Official Full Name
molybdenum cofactor sulfurase
NCBI Official Synonym Full Names
molybdenum cofactor sulfurase
NCBI Official Symbol
MOCOS
NCBI Official Synonym Symbols
MCS; MOS; HMCS
UniProt Protein Name
Molybdenum cofactor sulfurase
UniProt Synonym Protein Names
Molybdenum cofactor sulfurtransferase
Protein Family
Molybdenum cofactor sulfurase
UniProt Gene Name
MOCOS
UniProt Synonym Gene Names
MCS; MOS; MoCo sulfurase; hMCS
UniProt Entry Name
MOCOS_HUMAN
NCBI Protein Information
molybdenum cofactor sulfurase

NCBI Summary for MOCOS

MOCOS sulfurates the molybdenum cofactor of xanthine dehydrogenase (XDH; MIM 607633) and aldehyde oxidase (AOX1; MIM 602841), which is required for their enzymatic activities (Ichida et al., 2001 [PubMed 11302742]).[supplied by OMIM, Feb 2010]

UniProt Comments for MOCOS

MOCOS: Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form. In vitro, the C-terminal domain is able to reduce N-hydroxylated prodrugs, such as benzamidoxime. Defects in MOCOS are the cause of xanthinuria type 2 (XU2). Xanthinuria is characterized by excretion of very large amounts of xanthine in the urine and a tendency to form xanthine stones. Uric acid is strikingly diminished in serum and urine. In addition, patient suffering of XU2 cannot metabolize allopurinol into oxypurinol due to dual deficiency of xanthine dehydrogenase and aldehyde oxidase. Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily.

Protein type: EC 2.8.1.9; Lyase

Chromosomal Location of Human Ortholog: 18q12

Cellular Component: cytosol

Molecular Function: lyase activity; Mo-molybdopterin cofactor sulfurase activity; molybdenum ion binding; protein binding; pyridoxal phosphate binding; transferase activity

Biological Process: Mo-molybdopterin cofactor biosynthetic process; molybdopterin cofactor biosynthetic process; molybdopterin cofactor metabolic process; vitamin metabolic process; water-soluble vitamin metabolic process
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Research Articles on MOCOS

1. MOCOS sulfurates the molybdenum cofactor of xanthine oxidase (XDH) and aldehyde oxidase 1 (AOX1), which is required for their activities.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with MOCOS elisa kit

 Reference Product  PubMed Publications
 XDH elisa kit  >5 publications with MOCOS and XDH
 AOX1 elisa kit  >2 publications with MOCOS and AOX1

Pathways associated with MOCOS elisa kit

 Products by Pathway  Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Vitamins And Cofactors Pathway antibodies  Metabolism Of Vitamins And Cofactors Pathway Diagram
 Metabolism Of Water-soluble Vitamins And Cofactors Pathway antibodies  Metabolism Of Water-soluble Vitamins And Cofactors Pathway Diagram
 Molybdenum Cofactor Biosynthesis Pathway antibodies  Molybdenum Cofactor Biosynthesis Pathway Diagram
 Thio-molybdenum Cofactor Biosynthesis Pathway antibodies  Thio-molybdenum Cofactor Biosynthesis Pathway Diagram

Diseases associated with MOCOS elisa kit

 Disease Name  Pubmed Publications
 Hypertension Antibodies  >1 publications with MOCOS and Hypertension
 Nervous System Diseases Antibodies  >1 publications with MOCOS and Nervous System Diseases
 Kidney Diseases Antibodies  >1 publications with MOCOS and Kidney Diseases

Organs/Tissues associated with MOCOS elisa kit

 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >2 publications with MOCOS and Skin
 Brain Antibodies  >1 publications with MOCOS and Brain
 Intestine Antibodies  >1 publications with MOCOS and Intestine
 Liver Antibodies  >1 publications with MOCOS and Liver
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