Calmodulin (CAM) ELISA Kit for Rat

This gene encodes a member of the EF-hand calcium-binding protein family. It is one of three genes which encode an identical calcium binding protein which is one of the four subunits of phosphorylase kinase. Two pseudogenes have been identified on chromosome 7 and X. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]

Calmodulin: a calcium-binding small regulatory protein that mediates the control of a large number of enzymes by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Has four functional calcium-binding domains. Phosphorylation and ubiquitination result in a decreased activity.

Protein type: Calcium-binding

Chromosomal Location of Human Ortholog: 14q32.11

Cellular Component: centrosome; cytoplasm; cytosol; extracellular region; growth cone; nucleoplasm; nucleus; plasma membrane; sarcomere; spindle microtubule; spindle pole; vesicle

Molecular Function: adenylate cyclase binding; calcium ion binding; calcium-dependent protein binding; N-terminal myristoylation domain binding; nitric-oxide synthase binding; nitric-oxide synthase regulator activity; phosphoinositide 3-kinase binding; phospholipase binding; protein binding; protein domain specific binding; protein kinase binding; protein serine/threonine kinase activator activity; thioesterase binding; titin binding; type 3 metabotropic glutamate receptor binding

Biological Process: activation of MAPKK activity; adenylate cyclase activation; axon guidance; blood coagulation; carbohydrate metabolic process; detection of calcium ion; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; G-protein coupled receptor protein signaling pathway; glucose metabolic process; glycogen catabolic process; innate immune response; inositol phosphate metabolic process; insulin receptor signaling pathway; MAPKKK cascade; muscle contraction; nerve growth factor receptor signaling pathway; nitric oxide metabolic process; phospholipase C activation; phototransduction, visible light; platelet activation; platelet degranulation; positive regulation of cyclic nucleotide metabolic process; positive regulation of cyclic-nucleotide phosphodiesterase activity; positive regulation of nitric-oxide synthase activity; positive regulation of phosphoprotein phosphatase activity; positive regulation of protein amino acid autophosphorylation; positive regulation of protein amino acid dephosphorylation; Ras protein signal transduction; regulation of cytokinesis; regulation of heart rate; regulation of nitric-oxide synthase activity; regulation of rhodopsin mediated signaling; response to amphetamine; response to calcium ion; response to corticosterone stimulus; rhodopsin mediated signaling; signal transduction; small GTPase mediated signal transduction; stimulatory C-type lectin receptor signaling pathway; substantia nigra development; synaptic transmission; vascular endothelial growth factor receptor signaling pathway

Disease: Long Qt Syndrome 14; Ventricular Tachycardia, Catecholaminergic Polymorphic, 4