Troponin 1 Type 3, Cardiac (TNNI3) ELISA Kit for Sheep

Name: Sheep TNNI3 ELISA Kit; Troponin 1 Type 3, Cardiac; MyBioSource
Brand: MyBioSource
SKU: MBS076318
Price: 675 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS076318

MBS076318 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Troponin I Type 3, Cardiac (TNNI3) ELISA Kit target analytes in biological samples. The concentration gradients of the kit… More details

$675 / 48-Strip-Wells +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Request Current Manual

Product Overview

Online Datasheet in PDF

Product Name

Troponin I Type 3, Cardiac (TNNI3), ELISA Kit

Full Product Name

Sheep Troponin I Type 3, Cardiac ELISA Kit

Product Gene Name

TNNI3 elisa kit

Species Reactivity

Sheep

Preparation and Storage

Store all reagents at 2-8 degree C

Molecular Weight

35,924 Da

OMIM

115195

3D Structure

ModBase 3D Structure for P45379

Other Notes

Small volumes of TNNI3 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TNNI3. It may not necessarily be applicable to this product.

NCBI GI #

48255881

NCBI GeneID

7139

NCBI Accession #

NP_001001431.1

UniProt Primary Accession #

P45379

UniProt Secondary Accession #

O60214; Q99596; Q99597; Q9BUF6; Q9UM96; A2TDB9; A8K3K6

UniProt Related Accession #

P45379

GenBank Nucleotide #

NM_001001431.2

NCBI Official Full Name

troponin T, cardiac muscle isoform 3

NCBI Official Synonym Full Names

troponin T type 2 (cardiac)

NCBI Official Symbol

TNNT2

NCBI Official Synonym Symbols

CMH2; RCM3; TnTC; cTnT; CMD1D; CMPD2; LVNC6

UniProt Protein Name

Troponin T, cardiac muscle

UniProt Synonym Protein Names

Cardiac muscle troponin T

Protein Family

Troponin

UniProt Gene Name

TNNT2

UniProt Synonym Gene Names

TnTc; cTnT

UniProt Entry Name

TNNT2_HUMAN

NCBI Protein Information

troponin T, cardiac muscle; troponin T2, cardiac; cardiomyopathy, hypertrophic 2; cardiomyopathy, dilated 1D (autosomal dominant)

NCBI Summary for TNNI3

The protein encoded by this gene is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for this gene undergo alternative splicing that results in many tissue-specific isoforms, however, the full-length nature of some of these variants has not yet been determined. [provided by RefSeq, Jul 2008]

UniProt Comments for TNNI3

TNNT2: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Heart. The fetal heart shows a greater expression in the atrium than in the ventricle, while the adult heart shows a greater expression in the ventricle than in the atrium. Isoform 6 predominates in normal adult heart. Isoforms 1, 7 and 8 are expressed in fetal heart. Isoform 7 is also expressed in failing adult heart. Belongs to the troponin T family. 11 isoforms of the human protein are produced by alternative splicing.

Protein type: Motor; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 1q32

Cellular Component: sarcomere; troponin complex; cytosol; striated muscle thin filament

Molecular Function: troponin C binding; structural constituent of cytoskeleton; troponin I binding; ATPase activity; tropomyosin binding; actin binding

Biological Process: metabolic process; atrial cardiac muscle morphogenesis; positive regulation of ATPase activity; regulation of muscle contraction; ventricular cardiac muscle morphogenesis; sarcomere organization; response to calcium ion; negative regulation of ATPase activity; regulation of heart contraction; muscle filament sliding

Disease: Cardiomyopathy, Familial Restrictive, 3; Cardiomyopathy, Dilated, 1d; Cardiomyopathy, Familial Hypertrophic, 2

Research Articles on TNNI3

1. Familial hypertrophic cardiomyopathy mutants cTnI R145G and cTnT R278C were tested alone and together in motility assays. Sliding at low Ca2+ (diastolic dysfunction) with cTnI R145G is worsened by cTnT R278C.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with TNNI3 elisa kit

Reference Product	PubMed Publications
MYBPC3 elisa kit	>72 publications with TNNI3 and MYBPC3
TNNI3 elisa kit	>56 publications with TNNI3 and TNNI3
TPM1 elisa kit	>36 publications with TNNI3 and TPM1
MYL2 elisa kit	>22 publications with TNNI3 and MYL2
MYL3 elisa kit	>19 publications with TNNI3 and MYL3
TNNC1 elisa kit	>13 publications with TNNI3 and TNNC1
TTN elisa kit	>8 publications with TNNI3 and TTN
TNNI2 elisa kit	>1 publications with TNNI3 and TNNI2
TNNI1 elisa kit	>1 publications with TNNI3 and TNNI1

Pathways associated with TNNI3 elisa kit

Products by Pathway	Pathway Diagram
Adrenergic Signaling In Cardiomyocytes Pathway antibodies	Adrenergic Signaling In Cardiomyocytes Pathway Diagram
Adrenergic Signaling In Cardiomyocytes Pathway antibodies	Adrenergic Signaling In Cardiomyocytes Pathway Diagram
Cardiac Progenitor Differentiation Pathway antibodies	Cardiac Progenitor Differentiation Pathway Diagram
Cardiac Muscle Contraction Pathway antibodies	Cardiac Muscle Contraction Pathway Diagram
Cardiac Muscle Contraction Pathway antibodies	Cardiac Muscle Contraction Pathway Diagram
Dilated Cardiomyopathy Pathway antibodies	Dilated Cardiomyopathy Pathway Diagram
Dilated Cardiomyopathy Pathway antibodies	Dilated Cardiomyopathy Pathway Diagram
Hypertrophic Cardiomyopathy (HCM) Pathway antibodies	Hypertrophic Cardiomyopathy (HCM) Pathway Diagram
Hypertrophic Cardiomyopathy (HCM) Pathway antibodies	Hypertrophic Cardiomyopathy (HCM) Pathway Diagram
Muscle Contraction Pathway antibodies	Muscle Contraction Pathway Diagram

Diseases associated with TNNI3 elisa kit

Disease Name	Pubmed Publications
Cardiovascular Diseases Antibodies	>153 publications with TNNI3 and Cardiovascular Diseases
Heart Diseases Antibodies	>150 publications with TNNI3 and Heart Diseases
Cardiomyopathies Antibodies	>115 publications with TNNI3 and Cardiomyopathies
Cardiomyopathy, Hypertrophic Antibodies	>102 publications with TNNI3 and Cardiomyopathy, Hypertrophic
Cardiomyopathy, Hypertrophic, Familial Antibodies	>47 publications with TNNI3 and Cardiomyopathy, Hypertrophic, Familial
Cardiomyopathy, Dilated Antibodies	>44 publications with TNNI3 and Cardiomyopathy, Dilated
Cardiomegaly Antibodies	>40 publications with TNNI3 and Cardiomegaly
Hypertrophy Antibodies	>39 publications with TNNI3 and Hypertrophy
Heart Failure Antibodies	>35 publications with TNNI3 and Heart Failure
Death, Sudden, Cardiac Antibodies	>33 publications with TNNI3 and Death, Sudden, Cardiac

Organs/Tissues associated with TNNI3 elisa kit

Organ/Tissue Name	Pubmed Publications
Heart Antibodies	>117 publications with TNNI3 and Heart
Muscle Antibodies	>94 publications with TNNI3 and Muscle
Blood Antibodies	>48 publications with TNNI3 and Blood
Embryonic Tissue Antibodies	>15 publications with TNNI3 and Embryonic Tissue
Kidney Antibodies	>7 publications with TNNI3 and Kidney
Lung Antibodies	>4 publications with TNNI3 and Lung
Brain Antibodies	>4 publications with TNNI3 and Brain
Connective Tissue Antibodies	>2 publications with TNNI3 and Connective Tissue
Liver Antibodies	>2 publications with TNNI3 and Liver
Eye Antibodies	>1 publications with TNNI3 and Eye