Complement 1 Inhibitor (C1INH) ELISA Kit for Mouse

Name: Mouse C1INH ELISA Kit; Complement 1 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS763209
Price: 405 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS763209

Principle of the Assay: This kit was based on sandwich enzyme-linked immune-sorbent assay technology. Capture antibody was pre-coated onto 96-well plates. And the biotin conjugated antibody was used as detection antibodies. The standards, test samples and… More details

$405 / 48-Strip-Wells +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

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Product Overview

Online Datasheet in PDF

Product Name

Complement 1 Inhibitor (C1INH), ELISA Kit

Full Product Name

Mouse Complement 1 Inhibitor ELISA Kit

Product Gene Name

C1INH elisa kit

Product Synonym Names

C1INH/SERPING1/C1IN/C1INH/C1NH/HAE1/HAE2/C1 Inhibitor/C1IN/C1INH/C1NH/HAE1/HAE2/SERPING1 serpin peptidase inhibitor; clade G (C1 inhibitor); member 1/Plasma protease C1 inhibitor/Serpin G1/C1 esterase inhibitor/C1-inhibiting factor

Species Reactivity

Mouse

Assay Type

Sandwich ELISA, Double Antibody

Samples

Serum, Plasma, Cell Culture Supernatant, cell or tissue lysate, Other liquid samples

Detection Range

3.125-200ng/ml

Sensitivity

1.875ng/ml

Specificity

This assay has high sensitivity and excellent specificity for detection of C1INH. No significant cross-reactivity or interference between C1INH and analogues was observed.

Preparation and Storage

Store entire kit at 2-8C for short-term. For longer-term, please store the microplate & standard at -20C, while the remaining reagents can be stored at 2-8C

Inter-assay Precision

CV<10%

Intra-assay Precision

CV<8%

Molecular Weight

55,769 Da

OMIM

106100

ISO Certification

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Other Notes

Small volumes of C1INH elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for C1INH purchase

MBS763209 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Complement 1 Inhibitor (C1INH) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing C1INH. The ELISA analytical biochemical technique of the MBS763209 kit is based on C1INH antibody-C1INH antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect C1INH antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, C1INH. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for C1INH. It may not necessarily be applicable to this product.

NCBI GI #

33465583

NCBI GeneID

710

NCBI Accession #

AAQ19269.1

UniProt Secondary Accession #

Q16304; Q547W3; Q59EI5; Q7Z455; Q96FE0; Q9UC49; A6NMU0; A8KAI9; B2R6L5; B4E1F0; B4E1H2

UniProt Related Accession #

P05155

NCBI Official Full Name

C1 inhibitor mutant, partial

NCBI Official Synonym Full Names

serpin peptidase inhibitor, clade G (C1 inhibitor), member 1

NCBI Official Symbol

SERPING1

NCBI Official Synonym Symbols

C1IN; C1NH; HAE1; HAE2; C1INH

UniProt Protein Name

Plasma protease C1 inhibitor

UniProt Synonym Protein Names

C1 esterase inhibitor; C1-inhibiting factor; Serpin G1

UniProt Gene Name

SERPING1

UniProt Synonym Gene Names

C1IN; C1NH; C1 Inh; C1Inh

UniProt Entry Name

IC1_HUMAN

NCBI Protein Information

plasma protease C1 inhibitor

NCBI Summary for C1INH

This gene encodes a highly glycosylated plasma protein involved in the regulation of the complement cascade. Its protein inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. Deficiency of this protein is associated with hereditary angioneurotic oedema (HANE). Alternative splicing results in multiple transcript variants encoding the same isoform. [provided by RefSeq, Jul 2008]

UniProt Comments for C1INH

SERPING1: a protein protease inhibitor (C1-inhibitor) that forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play an important role in regulating complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Mutations of the SERPING1 gene is associated with adult macular degeneration can also cause hereditary angioedema. Binds to E.coli stcE which allows localization of SERPING1 to cell membranes thus protecting the bacteria against complement-mediated lysis. Belongs to the serpin family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 11q12.1

Cellular Component: extracellular region; extracellular space

Molecular Function: protein binding; serine-type endopeptidase inhibitor activity

Biological Process: aging; blood circulation; blood coagulation; blood coagulation, intrinsic pathway; complement activation, classical pathway; fibrinolysis; innate immune response; negative regulation of complement activation, lectin pathway; platelet activation; platelet degranulation

Disease: Angioedema, Hereditary, Type I; Complement Component 4, Partial Deficiency Of

Research Articles on C1INH

1. The levels of MASP-1 and MASP-1/C1-INH complexes are reduced in HAE patients compared with controls. Both MASP-1 and MASP-1/C1-INH complexes are related to the degree of complement C4 consumption

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with C1INH elisa kit

Reference Product	PubMed Publications
F12 elisa kit	>11 publications with C1INH and F12
C1R elisa kit	>7 publications with C1INH and C1R
MASP2 elisa kit	>4 publications with C1INH and MASP2
C1QA elisa kit	>1 publications with C1INH and C1QA

Pathways associated with C1INH elisa kit

Products by Pathway	Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Formation Of Fibrin Clot (Clotting Cascade) Pathway antibodies	Formation Of Fibrin Clot (Clotting Cascade) Pathway Diagram
Hemostasis Pathway antibodies	Hemostasis Pathway Diagram
Intrinsic Pathway Of Fibrin Clot Formation antibodies	Intrinsic Pathway Of Fibrin Clot Formation Diagram
Pertussis Pathway antibodies	Pertussis Pathway Diagram
Pertussis Pathway antibodies	Pertussis Pathway Diagram
Platelet Activation, Signaling And Aggregation Pathway antibodies	Platelet Activation, Signaling And Aggregation Pathway Diagram
Platelet Degranulation Pathway antibodies	Platelet Degranulation Pathway Diagram

Diseases associated with C1INH elisa kit

Disease Name	Pubmed Publications
Angioedemas, Hereditary Antibodies	>114 publications with C1INH and Angioedemas, Hereditary
Edema Antibodies	>70 publications with C1INH and Edema
Inflammation Antibodies	>29 publications with C1INH and Inflammation
Hereditary Angioedema Types I and II Antibodies	>19 publications with C1INH and Hereditary Angioedema Types I and II
Acquired angioedema Antibodies	>14 publications with C1INH and Acquired angioedema
Disease Models, Animal Antibodies	>14 publications with C1INH and Disease Models, Animal
Brain Diseases Antibodies	>8 publications with C1INH and Brain Diseases
Necrosis Antibodies	>7 publications with C1INH and Necrosis
Kidney Diseases Antibodies	>5 publications with C1INH and Kidney Diseases
Heart Diseases Antibodies	>5 publications with C1INH and Heart Diseases

Organs/Tissues associated with C1INH elisa kit

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>102 publications with C1INH and Blood
Vascular Antibodies	>31 publications with C1INH and Vascular
Skin Antibodies	>28 publications with C1INH and Skin
Larynx Antibodies	>16 publications with C1INH and Larynx
Eye Antibodies	>12 publications with C1INH and Eye
Heart Antibodies	>9 publications with C1INH and Heart
Muscle Antibodies	>7 publications with C1INH and Muscle
Liver Antibodies	>7 publications with C1INH and Liver
Kidney Antibodies	>6 publications with C1INH and Kidney
Lung Antibodies	>6 publications with C1INH and Lung