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Bone Morphogenetic Protein 6 (BMP-6) ELISA Kit for Mouse

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS763317

Principle of the Assay: This kit was based on sandwich enzyme-linked immune-sorbent assay technology. Capture antibody was pre-coated onto 96-well plates. And the biotin conjugated antibody was used as detection antibodies. The standards, test samples and… More details

$405 / 48-Strip-Wells +1 FREE 8GB USB

Product Documentation

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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Bone Morphogenetic Protein 6 (BMP-6), ELISA Kit
Full Product Name
Mouse Bone Morphogenetic Protein 6 ELISA Kit
Product Gene Name
BMP-6 elisa kit
Product Synonym Names
BMP-6 (Bone Morphogenetic Protein 6)/BMP6/VGR/VGR1
Species Reactivity
Mouse
Assay Type
Sandwich ELISA, Double Antibody
Samples
Serum, Plasma, Cell Culture Supernatant, cell or tissue lysate, Other liquid samples
Detection Range
78.125-5000pg/ml
Sensitivity
46.875pg/ml
Specificity
This assay has high sensitivity and excellent specificity for detection of BMP-6. No significant cross-reactivity or interference between BMP-6 and analogues was observed.
Preparation and Storage
Store entire kit at 2-8C for short-term. For longer-term, please store the microplate & standard at -20C, while the remaining reagents can be stored at 2-8C
Inter-assay Precision
CV<10%
Intra-assay Precision
CV<8%
Molecular Weight
57,226 Da
OMIM
112266
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Typical Testing Data/Standard Curve (for reference only) of BMP-6 elisa kit

Mouse BMP-6 ELISA Kit – Cat# MBS763317

Other Notes

Small volumes of BMP-6 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BMP-6 purchase

MBS763317 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Bone Morphogenetic Protein 6 (BMP-6) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing BMP-6. The ELISA analytical biochemical technique of the MBS763317 kit is based on BMP-6 antibody-BMP-6 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect BMP-6 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, BMP-6. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for BMP-6. It may not necessarily be applicable to this product.

NCBI GI #
3492993
NCBI GeneID
654
NCBI Accession #
AAC33283.1
UniProt Secondary Accession #
Q5TCP3
UniProt Related Accession #
P22004
NCBI Official Full Name
bone morphogenetic protein 6, partial
NCBI Official Synonym Full Names
bone morphogenetic protein 6
NCBI Official Symbol
BMP6
NCBI Official Synonym Symbols
VGR; VGR1
UniProt Protein Name
Bone morphogenetic protein 6
UniProt Synonym Protein Names
VG-1-related protein; VG-1-R; VGR-1
Protein Family
Bone morphogenetic protein
UniProt Gene Name
BMP6
UniProt Synonym Gene Names
VGR; BMP-6; VG-1-R; VGR-1
UniProt Entry Name
BMP6_HUMAN
NCBI Protein Information
bone morphogenetic protein 6

NCBI Summary for BMP-6

The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has lead to speculation of possible bone inductive activity. [provided by RefSeq, Jul 2008]
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UniProt Comments for BMP-6

BMP6: Induces cartilage and bone formation. Belongs to the TGF-beta family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 6p24-p23

Cellular Component: cytoplasm; extracellular space

Molecular Function: cytokine activity; growth factor activity; protein heterodimerization activity; transforming growth factor beta receptor binding

Biological Process: BMP signaling pathway; cartilage development; cellular iron ion homeostasis; endochondral ossification; eye development; growth; immune response; inflammatory response; kidney development; male genitalia development; negative regulation of transcription from RNA polymerase II promoter; osteoblast differentiation; positive regulation of aldosterone biosynthetic process; positive regulation of bone mineralization; positive regulation of chondrocyte differentiation; positive regulation of endothelial cell differentiation; positive regulation of endothelial cell proliferation; positive regulation of epithelial cell proliferation; positive regulation of lipopolysaccharide-mediated signaling pathway; positive regulation of neuron differentiation; positive regulation of osteoblast differentiation; positive regulation of protein secretion; positive regulation of transcription from RNA polymerase II promoter; regulation of apoptosis; regulation of MAPKKK cascade; response to activity; response to glucocorticoid stimulus; response to magnesium ion; response to retinoic acid; skeletal development
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Research Articles on BMP-6

1. These observations imply that crosstalk between the VEGF and BMP-6 signaling pathways enhances osteogenic differentiation of MSCs.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with BMP-6 elisa kit

 Reference Product  PubMed Publications
 BMPR2 elisa kit  >61 publications with BMP-6 and BMPR2
 SMAD1 elisa kit  >60 publications with BMP-6 and SMAD1
 SMAD5 elisa kit  >30 publications with BMP-6 and SMAD5
 BMPR1A elisa kit  >18 publications with BMP-6 and BMPR1A
 BMPR1B elisa kit  >17 publications with BMP-6 and BMPR1B
 SMAD7 elisa kit  >11 publications with BMP-6 and SMAD7
 ACVR2A elisa kit  >5 publications with BMP-6 and ACVR2A
 NOG elisa kit  >3 publications with BMP-6 and NOG

Pathways associated with BMP-6 elisa kit

 Products by Pathway  Pathway Diagram
 BMP Receptor Signaling Pathway antibodies  BMP Receptor Signaling Pathway Diagram
 BMP Signaling Pathway antibodies  BMP Signaling Pathway Diagram
 BMP Signaling Pathway antibodies  BMP Signaling Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Id Signaling Pathway antibodies  Id Signaling Pathway Diagram
 Ovarian Steroidogenesis Pathway antibodies  Ovarian Steroidogenesis Pathway Diagram
 Ovarian Steroidogenesis Pathway antibodies  Ovarian Steroidogenesis Pathway Diagram
 TGF-beta Signaling Pathway antibodies  TGF-beta Signaling Pathway Diagram

Diseases associated with BMP-6 elisa kit

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >40 publications with BMP-6 and Inflammation
 Anemia Antibodies  >38 publications with BMP-6 and Anemia
 Hemochromatosis Antibodies  >31 publications with BMP-6 and Hemochromatosis
 Disease Models, Animal Antibodies  >31 publications with BMP-6 and Disease Models, Animal
 Liver Diseases Antibodies  >22 publications with BMP-6 and Liver Diseases
 Fibrosis Antibodies  >15 publications with BMP-6 and Fibrosis
 Kidney Diseases Antibodies  >13 publications with BMP-6 and Kidney Diseases
 Necrosis Antibodies  >13 publications with BMP-6 and Necrosis
 Nervous System Diseases Antibodies  >13 publications with BMP-6 and Nervous System Diseases
 Osteoarthritis Antibodies  >9 publications with BMP-6 and Osteoarthritis

Organs/Tissues associated with BMP-6 elisa kit

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >97 publications with BMP-6 and Blood
 Connective Tissue Antibodies  >48 publications with BMP-6 and Connective Tissue
 Ovary Antibodies  >42 publications with BMP-6 and Ovary
 Embryonic Tissue Antibodies  >34 publications with BMP-6 and Embryonic Tissue
 Brain Antibodies  >32 publications with BMP-6 and Brain
 Vascular Antibodies  >31 publications with BMP-6 and Vascular
 Prostate Antibodies  >26 publications with BMP-6 and Prostate
 Kidney Antibodies  >23 publications with BMP-6 and Kidney
 Mouth Antibodies  >19 publications with BMP-6 and Mouth
 Lung Antibodies  >13 publications with BMP-6 and Lung
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