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Lysophosphatidic Acid Receptor 1 (LPAR1) ELISA Kit for Human

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS763386

Principle of the Assay||This kit was based on sandwich enzyme-linked immune-sorbent assay technology. anti-Human LPAR1 antibody was pre-coated onto 96-well plates. And the biotin conjugated anti-Human LPAR1 antibody was used as detection antibodies. The… More details

$405 / 48-Strip-Wells +1 FREE 8GB USB

Product Documentation

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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Lysophosphatidic acid receptor 1 (LPAR1), ELISA Kit
Full Product Name
Human Lysophosphatidic acid receptor 1 ELISA Kit
Product Gene Name
LPAR1 elisa kit
Product Synonym Names
LPAR1/Lysophosphatidic acid receptor Edg-2/LPA receptor 1/LPA-1/EDG2/LPA1
Species Reactivity
Human
Assay Type
Sandwich ELISA, Double Antibody
Samples
Serum, Plasma, Cell Culture Supernatant, cell or tissue lysate, Other liquid samples
Detection Range
0.313-20ng/ml
Sensitivity
0.188ng/ml
Preparation and Storage
Store entire kit at 2-8C for short-term. For longer-term, please store the microplate & standard at -20C, while the remaining reagents can be stored at 2-8C
Molecular Weight
41,346 Da
OMIM
602282
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Typical Testing Data of LPAR1 elisa kit

Human LPAR1 ELISA Kit – Cat# MBS763386

Typical Standard Curve of LPAR1 elisa kit

Human LPAR1 ELISA Kit, Typical Standard Curve – Cat# MBS763386

Other Notes

Small volumes of LPAR1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LPAR1 purchase

MBS763386 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Lysophosphatidic acid receptor 1 (LPAR1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing LPAR1. The ELISA analytical biochemical technique of the MBS763386 kit is based on LPAR1 antibody-LPAR1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect LPAR1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, LPAR1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for LPAR1. It may not necessarily be applicable to this product.

NCBI GI #
16950638
NCBI GeneID
1902
NCBI Accession #
NP_476500.1
UniProt Secondary Accession #
O00656; O00722; P78351; B4DK36
UniProt Related Accession #
Q92633
GenBank Nucleotide #
NM_057159.2
NCBI Official Full Name
lysophosphatidic acid receptor 1
NCBI Official Synonym Full Names
lysophosphatidic acid receptor 1
NCBI Official Symbol
LPAR1
NCBI Official Synonym Symbols
EDG2; LPA1; VZG1; GPR26; edg-2; vzg-1; Gpcr26; Mrec1.3; rec.1.3
UniProt Protein Name
Lysophosphatidic acid receptor 1
UniProt Synonym Protein Names
Lysophosphatidic acid receptor Edg-2
Protein Family
Lysophosphatidic acid receptor
UniProt Gene Name
LPAR1
UniProt Synonym Gene Names
EDG2; LPA1; LPA receptor 1; LPA-1
UniProt Entry Name
LPAR1_HUMAN
NCBI Protein Information
lysophosphatidic acid receptor 1

NCBI Summary for LPAR1

The integral membrane protein encoded by this gene is a lysophosphatidic acid (LPA) receptor from a group known as EDG receptors. These receptors are members of the G protein-coupled receptor superfamily. Utilized by LPA for cell signaling, EDG receptors mediate diverse biologic functions, including proliferation, platelet aggregation, smooth muscle contraction, inhibition of neuroblastoma cell differentiation, chemotaxis, and tumor cell invasion. Two transcript variants encoding the same protein have been identified for this gene [provided by RefSeq, Jul 2008]
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UniProt Comments for LPAR1

LPAR1: Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Stimulates phospholipase C (PLC) activity in a manner that is dependent on RALA activation. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR; GPCR, family 1

Chromosomal Location of Human Ortholog: 9q31.3

Cellular Component: cell soma; cell surface; cytosol; dendritic shaft; dendritic spine; endocytic vesicle; endosome; integral to plasma membrane; plasma membrane

Molecular Function: G-protein alpha-subunit binding; G-protein coupled receptor activity; PDZ domain binding; protein binding

Biological Process: activation of MAPK activity; bleb formation; cerebellum development; corpus callosum development; elevation of cytosolic calcium ion concentration; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); G-protein coupled receptor protein signaling pathway; G-protein signaling, adenylate cyclase inhibiting pathway; myelination; negative regulation of cAMP biosynthetic process; oligodendrocyte development; optic nerve development; phospholipase C activation; positive regulation of apoptosis; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of MAPKKK cascade; positive regulation of Rho protein signal transduction; positive regulation of stress fiber formation; regulation of cell shape
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Research Articles on LPAR1

1. we show that LPAR1 is a novel susceptibility gene for human essential hypertension and that stress, such as shortage of sleep, increases the susceptibility of patients with risk allele to essential hypertension.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with LPAR1 elisa kit

 Reference Product  PubMed Publications
 LPAR6 elisa kit  >6 publications with LPAR1 and LPAR6
 LPAR5 elisa kit  >5 publications with LPAR1 and LPAR5
 LPAR4 elisa kit  >5 publications with LPAR1 and LPAR4

Pathways associated with LPAR1 elisa kit

 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Gap Junction Pathway antibodies  Gap Junction Pathway Diagram
 Gap Junction Pathway antibodies  Gap Junction Pathway Diagram
 Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies  Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
 LPA Receptor Mediated Events Pathway antibodies  LPA Receptor Mediated Events Pathway Diagram
 Lysosphingolipid And LPA Receptors Pathway antibodies  Lysosphingolipid And LPA Receptors Pathway Diagram

Diseases associated with LPAR1 elisa kit

 Disease Name  Pubmed Publications
 Fibrosis Antibodies  >6 publications with LPAR1 and Fibrosis
 Nervous System Diseases Antibodies  >6 publications with LPAR1 and Nervous System Diseases
 Inflammation Antibodies  >5 publications with LPAR1 and Inflammation
 Disease Models, Animal Antibodies  >4 publications with LPAR1 and Disease Models, Animal
 Hypertension Antibodies  >4 publications with LPAR1 and Hypertension
 Liver Neoplasms Antibodies  >3 publications with LPAR1 and Liver Neoplasms
 Liver Diseases Antibodies  >3 publications with LPAR1 and Liver Diseases
 Carcinoma, Hepatocellular Antibodies  >3 publications with LPAR1 and Carcinoma, Hepatocellular
 Lung Neoplasms Antibodies  >2 publications with LPAR1 and Lung Neoplasms
 Mammary Neoplasms, Experimental Antibodies  >2 publications with LPAR1 and Mammary Neoplasms, Experimental

Organs/Tissues associated with LPAR1 elisa kit

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >11 publications with LPAR1 and Liver
 Lung Antibodies  >8 publications with LPAR1 and Lung
 Vascular Antibodies  >6 publications with LPAR1 and Vascular
 Uterus Antibodies  >6 publications with LPAR1 and Uterus
 Bone Antibodies  >5 publications with LPAR1 and Bone
 Nerve Antibodies  >5 publications with LPAR1 and Nerve
 Heart Antibodies  >5 publications with LPAR1 and Heart
 Muscle Antibodies  >4 publications with LPAR1 and Muscle
 Skin Antibodies  >3 publications with LPAR1 and Skin
 Bone Marrow Antibodies  >3 publications with LPAR1 and Bone Marrow
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