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Dysbindin (DTNBP1) ELISA Kit for Human

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS763402

Principle of the Assay||This kit was based on sandwich enzyme-linked immune-sorbent assay technology. Anti-DTNBP1 antibody was pre-coated onto 96-well plates. And the biotin conjugated anti-DTNBP1 antibody was used as detection antibodies. The standards, test… More details

$405 / 48-Strip-Wells +1 FREE 8GB USB

Product Documentation

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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Dysbindin (DTNBP1), ELISA Kit
Full Product Name
Human Dysbindin ELISA Kit
Product Gene Name
DTNBP1 elisa kit
Product Synonym Names
DTNBP1/Dysbindin/Hermansky-Pudlak syndrome 7 protein/HPS7 protein/Hermansky-Pudlak syndrome 7 protein/HPS7 protein/Dysbindin-1/BLOC-1 subunit 8/Dystrobrevin-binding protein 1/My031/BLOC1S8/DBND/HPS7
Species Reactivity
Human
Assay Type
Sandwich ELISA, Double Antibody
Samples
Serum, Plasma, Cell Culture Supernatant, cell or tissue lysate, Other liquid samples
Detection Range
78.125-5000pg/ml
Sensitivity
46.875pg/ml
Preparation and Storage
Store entire kit at 2-8C for short-term. For longer-term, please store the microplate & standard at -20C, while the remaining reagents can be stored at 2-8C
Molecular Weight
30,582 Da
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Typical Testing Data of DTNBP1 elisa kit

Human DTNBP1 ELISA Kit – Cat# MBS763402

Typical Standard Curve of DTNBP1 elisa kit

Human DTNBP1 ELISA Kit, Typical Standard Curve – Cat# MBS763402

Other Notes

Small volumes of DTNBP1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DTNBP1 purchase

MBS763402 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Dysbindin (DTNBP1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing DTNBP1. The ELISA analytical biochemical technique of the MBS763402 kit is based on DTNBP1 antibody-DTNBP1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect DTNBP1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, DTNBP1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for DTNBP1. It may not necessarily be applicable to this product.

NCBI GI #
15208633
NCBI GeneID
94245
NCBI Accession #
NP_080048.2
UniProt Secondary Accession #
Q3TWK1; Q6WXQ1; Q80ZN4; Q9CY43
UniProt Related Accession #
Q91WZ8
GenBank Nucleotide #
NM_025772.4
NCBI Official Full Name
dysbindin
NCBI Official Synonym Full Names
dystrobrevin binding protein 1
NCBI Official Symbol
Dtnbp1
NCBI Official Synonym Symbols
sdy; Bloc1s8; AW048963; dysbindin; 5430437B18Rik
UniProt Protein Name
Dysbindin
UniProt Synonym Protein Names
Biogenesis of lysosome-related organelles complex 1 subunit 8; BLOC-1 subunit 8; Dysbindin-1; Dystrobrevin-binding protein 1; Hermansky-Pudlak syndrome 7 protein homolog; HPS7 protein homolog
Protein Family
Dysbindin
UniProt Gene Name
Dtnbp1
UniProt Synonym Gene Names
Bloc1s8; Sdy; BLOC-1 subunit 8; HPS7 protein homolog
UniProt Entry Name
DTBP1_MOUSE
NCBI Protein Information
dysbindin

UniProt Comments for DTNBP1

DTNBP1: The BLOC-1 complex is required for normal biogenesis of lysosome-related organelles, such as platelet dense granules and melanosomes. Plays a role in intracellular vesicle trafficking. Plays a role in synaptic vesicle trafficking and in neurotransmitter release. May be required for normal dopamine homeostasis in the cerebral cortex, hippocampus, and hypothalamus. Plays a role in the regulation of cell surface exposure of DRD2. Contributes to the regulation of dopamine signaling. May play a role in actin cytoskeleton reorganization and neurite outgrowth. May modulate MAPK8 phosphorylation. Part of the biogenesis of lysosome-related organelles complex 1 (BLOC-1). The BLOC-1 complex is composed of BLOC1S1, BLOC1S2, BLOC1S3, DTNBP1, MUTED, PLDN, CNO/cappuccino and SNAPIN. Binds to DTNA and DTNB but may not be a physiological binding partner (PubMed:16980328). Interacts with RNF151 and CMYA5. Identified in a complex with the adapter-related protein complex 3 (AP-3). Interacts with TRIM32, AP3M1 and AP3B2. Identified in a complex with the biogenesis of lysosome-related organelles complex 2 (BLOC-2). Interacts with the DNA-dependent protein kinase complex DNA-PK. Detected in brain, in neurons and in neuropil. Detected in dentate gyrus and in pyramidal cells of hippocampus CA2 and CA3. Belongs to the dysbindin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Vesicle

Cellular Component: axon; cell junction; cytoplasm; cytoplasmic vesicle; dendritic spine; endoplasmic reticulum; endoplasmic reticulum membrane; endosome; growth cone; membrane; neuron projection; nucleus; plasma membrane; postsynaptic density; postsynaptic membrane; sarcolemma; sarcoplasm; synapse; synaptic vesicle membrane

Molecular Function: protein binding

Biological Process: actin cytoskeleton reorganization; anterograde axon cargo transport; anterograde synaptic vesicle transport; blood coagulation; muscle development; neurite development; neurite morphogenesis; organelle organization and biogenesis; platelet dense granule organization and biogenesis; positive regulation of neurotransmitter secretion; regulation of dopamine receptor signaling pathway; regulation of dopamine secretion; regulation of JNK activity; response to stimulus
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Research Articles on DTNBP1

1. Results suggest that Dtnbp1 deficiency may lead to increased vulnerability to schizophrenia under environmental conditions where circadian rhythms are altered

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with DTNBP1 elisa kit

 Reference Product  PubMed Publications
 Bloc1s1 elisa kit  >10 publications with DTNBP1 and Bloc1s1
 Bloc1s3 elisa kit  >6 publications with DTNBP1 and Bloc1s3
 Snapin elisa kit  >6 publications with DTNBP1 and Snapin
 Bloc1s5 elisa kit  >1 publications with DTNBP1 and Bloc1s5
 Bloc1s6 elisa kit  >1 publications with DTNBP1 and Bloc1s6

Pathways associated with DTNBP1 elisa kit

 Products by Pathway  Pathway Diagram
 Clathrin Derived Vesicle Budding Pathway antibodies  Clathrin Derived Vesicle Budding Pathway Diagram
 Golgi Associated Vesicle Biogenesis Pathway antibodies  Golgi Associated Vesicle Biogenesis Pathway Diagram
 Membrane Trafficking Pathway antibodies  Membrane Trafficking Pathway Diagram
 Vesicle-mediated Transport Pathway antibodies  Vesicle-mediated Transport Pathway Diagram
 Trans-Golgi Network Vesicle Budding Pathway antibodies  Trans-Golgi Network Vesicle Budding Pathway Diagram

Diseases associated with DTNBP1 elisa kit

 Disease Name  Pubmed Publications
 Schizophrenia Antibodies  >285 publications with DTNBP1 and Schizophrenia
 Mental Disorders Antibodies  >246 publications with DTNBP1 and Mental Disorders
 Cognition Disorders Antibodies  >28 publications with DTNBP1 and Cognition Disorders
 Disease Models, Animal Antibodies  >19 publications with DTNBP1 and Disease Models, Animal
 Nervous System Diseases Antibodies  >12 publications with DTNBP1 and Nervous System Diseases
 Depressive Disorder Antibodies  >11 publications with DTNBP1 and Depressive Disorder
 Learning Disorders Antibodies  >6 publications with DTNBP1 and Learning Disorders
 Neurobehavioral Manifestations Antibodies  >6 publications with DTNBP1 and Neurobehavioral Manifestations
 Poisoning Antibodies  >4 publications with DTNBP1 and Poisoning
 Cardiovascular Diseases Antibodies  >3 publications with DTNBP1 and Cardiovascular Diseases

Organs/Tissues associated with DTNBP1 elisa kit

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >151 publications with DTNBP1 and Brain
 Muscle Antibodies  >13 publications with DTNBP1 and Muscle
 Blood Antibodies  >10 publications with DTNBP1 and Blood
 Lung Antibodies  >4 publications with DTNBP1 and Lung
 Eye Antibodies  >3 publications with DTNBP1 and Eye
 Embryonic Tissue Antibodies  >2 publications with DTNBP1 and Embryonic Tissue
 Liver Antibodies  >1 publications with DTNBP1 and Liver
 Uncharacterized Tissue Antibodies  >1 publications with DTNBP1 and Uncharacterized Tissue
 Testis Antibodies  >1 publications with DTNBP1 and Testis
 Uterus Antibodies  >1 publications with DTNBP1 and Uterus
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