Mitogen-Activated Protein Kinase 8 (MAPK8) ELISA Kit for Human

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. [provided by RefSeq, Jul 2012]

JNK1: a protein kinase of the MAPK family that is potently activated by a variety of environmental stresses, including UV and gamma radiation, ceramides, pro-inflammatory cytokines and, in some instances, by growth factors and GPCR agonists. Substrates include a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2, thus regulating AP-1 transcriptional activity. In T- cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells. Binds to at least four scaffolding proteins, JIP-1, -2, -3 and -4. Activity increased in obesity. Inhibition or mouse knockout increases insulin sensitivity. Part of NFB pathway involved in inflammation and cancer, and signals downstream of Ras, though possibly as an apoptotic negative regulator of growth. Four alternatively-spliced isoforms have been described.

Protein type: Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Protein kinase, CMGC; EC 2.7.11.24; CMGC group; MAPK family; JNK subfamily; MAPK/JNK subfamily

Cellular Component: axon; cytoplasm; cytosol; dendrite cytoplasm; intracellular; mitochondrion; nucleus; perikaryon; podosome; vesicle

Molecular Function: ATP binding; enzyme binding; histone deacetylase binding; histone deacetylase regulator activity; JUN kinase activity; kinase activity; kinesin binding; MAP kinase activity; protein binding; protein serine/threonine kinase activity

Biological Process: dendrite morphogenesis; inflammatory response; JNK cascade; JUN phosphorylation; MAPKKK cascade; negative regulation of apoptosis; negative regulation of protein binding; neurite development; neuron development; neuron migration; ossification; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; positive regulation of apoptosis; positive regulation of cell migration; positive regulation of cyclase activity; positive regulation of DNA replication; positive regulation of microtubule polymerization; positive regulation of neuron apoptosis; positive regulation of protein metabolic process; protein amino acid phosphorylation; regulation of circadian rhythm; regulation of gene expression; regulation of histone deacetylation; regulation of protein localization; regulation of transcription, DNA-dependent; response to cadmium ion; response to heat; response to hydrogen peroxide; response to osmotic stress; response to steroid hormone stimulus; response to UV; rhythmic process; signal transduction