Integrin Beta-2 (ITGB2) ELISA Kit for Human

This gene encodes an integrin beta chain, which combines with multiple different alpha chains to form different integrin heterodimers. Integrins are integral cell-surface proteins that participate in cell adhesion as well as cell-surface mediated signalling. The encoded protein plays an important role in immune response and defects in this gene cause leukocyte adhesion deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

ITGB2: the integrin beta 2 subunit. Can combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Participates in cell adhesion as well as cell-surface mediated signaling. Defects are the cause of leukocyte adhesion deficiency type I (LAD1).

Protein type: Cell surface; Membrane protein, integral; Cell adhesion; Motility/polarity/chemotaxis; Receptor, misc.

Chromosomal Location of Human Ortholog: 21q22.3

Cellular Component: cell surface; integrin complex; membrane; plasma membrane; receptor complex

Molecular Function: cell adhesion molecule binding; glycoprotein binding; ICAM-3 receptor activity; metal ion binding; protein binding; protein complex binding; protein heterodimerization activity; protein kinase binding

Biological Process: activation of NF-kappaB transcription factor; aging; apoptosis; blood coagulation; cell adhesion; cell-cell signaling; cell-matrix adhesion; cellular extravasation; endothelial cell migration; extracellular matrix organization and biogenesis; heterotypic cell-cell adhesion; inflammatory response; innate immune response; integrin-mediated signaling pathway; leukocyte adhesion; leukocyte migration; leukocyte migration during inflammatory response; natural killer cell activation; neutrophil chemotaxis; positive regulation of angiogenesis; positive regulation of nitric oxide biosynthetic process; receptor clustering; receptor internalization; regulation of cell shape; regulation of immune response; regulation of peptidyl-tyrosine phosphorylation; toll-like receptor 4 signaling pathway; toll-like receptor signaling pathway

Disease: Leukocyte Adhesion Deficiency, Type I