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Integrin Alpha-L (ITGAL) ELISA Kit for Human

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS763838

Principle of the Assay||This kit was based on sandwich enzyme-linked immune-sorbent assay technology. Anti-Human ITGAL antibody was pre-coated onto 96-well plates. And the biotin conjugated anti-Human ITGAL antibody was used as detection antibodies. The… More details

$405 / 48-Strip-Wells +1 FREE 8GB USB

Product Documentation

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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Integrin alpha-L (ITGAL), ELISA Kit
Full Product Name
Human Integrin alpha-L ELISA Kit
Product Gene Name
ITGAL elisa kit
Product Synonym Names
ITGAL/Integrin alpha-L/Leukocyte function-associated molecule 1 alpha chain/CD11 antigen-like family member A/Leukocyte adhesion glycoprotein LFA-1 alpha chain/LFA-1A/CD11A/LFA-1/LFA1A
Species Reactivity
Human
Assay Type
Sandwich ELISA, Double Antibody
Samples
Serum, Plasma, Cell Culture Supernatant, cell or tissue lysate, Other liquid samples
Detection Range
0.313-20ng/ml
Sensitivity
0.188ng/ml
Preparation and Storage
Store entire kit at 2-8C for short-term. For longer-term, please store the microplate & standard at -20C, while the remaining reagents can be stored at 2-8C
Molecular Weight
119,224 Da
OMIM
153370
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Typical Testing Data of ITGAL elisa kit

Human ITGAL ELISA Kit – Cat# MBS763838

Typical Standard Curve of ITGAL elisa kit

Human ITGAL ELISA Kit, Typical Standard Curve – Cat# MBS763838

Other Notes

Small volumes of ITGAL elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ITGAL purchase

MBS763838 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Integrin alpha-L (ITGAL) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing ITGAL. The ELISA analytical biochemical technique of the MBS763838 kit is based on ITGAL antibody-ITGAL antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ITGAL antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ITGAL. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for ITGAL. It may not necessarily be applicable to this product.

NCBI GI #
167466215
NCBI GeneID
3683
NCBI Accession #
NP_002200.2
UniProt Secondary Accession #
O43746; Q45H73; Q96HB1; Q9UBC8
UniProt Related Accession #
P20701
GenBank Nucleotide #
NM_002209.2
NCBI Official Full Name
integrin alpha-L isoform a
NCBI Official Synonym Full Names
integrin subunit alpha L
NCBI Official Symbol
ITGAL
NCBI Official Synonym Symbols
CD11A; LFA-1; LFA1A
UniProt Protein Name
Integrin alpha-L
UniProt Synonym Protein Names
CD11 antigen-like family member A; Leukocyte adhesion glycoprotein LFA-1 alpha chain; LFA-1A; Leukocyte function-associated molecule 1 alpha chain; CD_antigen: CD11a
Protein Family
Integrin
UniProt Gene Name
ITGAL
UniProt Synonym Gene Names
CD11A; LFA-1A
UniProt Entry Name
ITAL_HUMAN
NCBI Protein Information
integrin alpha-L

NCBI Summary for ITGAL

ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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UniProt Comments for ITGAL

ITGAL: Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Belongs to the integrin alpha chain family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Cell surface; Membrane protein, integral; Cell adhesion

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: cell surface; external side of plasma membrane; immunological synapse; integrin complex; intercellular junction; membrane; plasma membrane

Molecular Function: cell adhesion molecule binding; ICAM-3 receptor activity; metal ion binding; protein binding; protein complex binding; protein heterodimerization activity

Biological Process: activated T cell proliferation; blood coagulation; cell adhesion; cell motility; cell-matrix adhesion; extracellular matrix organization and biogenesis; heterophilic cell adhesion; inflammatory response; integrin-mediated signaling pathway; leukocyte adhesion; leukocyte migration; positive regulation of calcium-mediated signaling; positive regulation of T cell proliferation; receptor clustering; regulation of immune response; signal transduction; T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
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Research Articles on ITGAL

1. beta2 integrins-mediated chemosensory adhesion and migration of polymorphonuclear leukocytes on the vascular graft surface, bacterial cellulose.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with ITGAL elisa kit

 Reference Product  PubMed Publications
 ITGB2 elisa kit  >1103 publications with ITGAL and ITGB2
 ICAM1 elisa kit  >482 publications with ITGAL and ICAM1
 ICAM2 elisa kit  >42 publications with ITGAL and ICAM2
 ICAM3 elisa kit  >37 publications with ITGAL and ICAM3
 CD226 elisa kit  >3 publications with ITGAL and CD226
 ITGB1 elisa kit  >3 publications with ITGAL and ITGB1
 CD8A elisa kit  >2 publications with ITGAL and CD8A
 ICAM5 elisa kit  >2 publications with ITGAL and ICAM5
 ITGB3 elisa kit  >1 publications with ITGAL and ITGB3

Pathways associated with ITGAL elisa kit

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 CXCR3-mediated Signaling Events Pathway antibodies  CXCR3-mediated Signaling Events Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram

Diseases associated with ITGAL elisa kit

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >252 publications with ITGAL and Inflammation
 Necrosis Antibodies  >219 publications with ITGAL and Necrosis
 Cardiovascular Diseases Antibodies  >109 publications with ITGAL and Cardiovascular Diseases
 Lung Diseases Antibodies  >70 publications with ITGAL and Lung Diseases
 Heart Diseases Antibodies  >26 publications with ITGAL and Heart Diseases
 Kidney Diseases Antibodies  >25 publications with ITGAL and Kidney Diseases
 Atherosclerosis Antibodies  >24 publications with ITGAL and Atherosclerosis
 Lung Injury Antibodies  >22 publications with ITGAL and Lung Injury
 Colitis Antibodies  >21 publications with ITGAL and Colitis
 Fibrosis Antibodies  >16 publications with ITGAL and Fibrosis

Organs/Tissues associated with ITGAL elisa kit

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1585 publications with ITGAL and Blood
 Bone Marrow Antibodies  >184 publications with ITGAL and Bone Marrow
 Lung Antibodies  >119 publications with ITGAL and Lung
 Lymph Antibodies  >86 publications with ITGAL and Lymph
 Lymph Node Antibodies  >78 publications with ITGAL and Lymph Node
 Spleen Antibodies  >76 publications with ITGAL and Spleen
 Intestine Antibodies  >53 publications with ITGAL and Intestine
 Brain Antibodies  >51 publications with ITGAL and Brain
 Liver Antibodies  >49 publications with ITGAL and Liver
 Kidney Antibodies  >49 publications with ITGAL and Kidney
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