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Bone Morphogenetic Protein Receptor 1a (BMPR-1A) ELISA Kit for Rat

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS763844

Principle of the Assay||This kit was based on sandwich enzyme-linked immune-sorbent assay technology. Anti-Rat BMPR-1A antibody was pre-coated onto 96-well plates. And the biotin conjugated anti-Rat BMPR-1A antibody was used as detection antibodies. The… More details

$405 / 48-Strip-Wells +1 FREE 8GB USB

Product Documentation

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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Bone Morphogenetic Protein Receptor 1A (BMPR-1A), ELISA Kit
Full Product Name
Rat Bone Morphogenetic Protein Receptor 1A ELISA Kit
Product Gene Name
BMPR-1A elisa kit
Product Synonym Names
BMPR-1A/Bone morphogenetic protein receptor type-1A/BMP type-1A receptor/BMPR-1A/Activin receptor-like kinase 3/ALK-3/Bone morphogenetic protein 4 receptor/CD292/
Species Reactivity
Rat
Assay Type
Sandwich ELISA, Double Antibody
Samples
Serum, Plasma, Cell Culture Supernatant, cell or tissue lysate, Other liquid samples
Detection Range
0.781-50ng/ml
Sensitivity
0.469ng/ml
Preparation and Storage
Store entire kit at 2-8C for short-term. For longer-term, please store the microplate & standard at -20C, while the remaining reagents can be stored at 2-8C
Molecular Weight
60,198 Da
OMIM
174900
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Typical Testing Data of BMPR-1A elisa kit

Rat BMPR-1A ELISA Kit – Cat# MBS763844

Typical Standard Curve of BMPR-1A elisa kit

Rat BMPR-1A ELISA Kit, Typical Standard Curve – Cat# MBS763844

Other Notes

Small volumes of BMPR-1A elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BMPR-1A purchase

MBS763844 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Bone Morphogenetic Protein Receptor 1A (BMPR-1A) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing BMPR-1A. The ELISA analytical biochemical technique of the MBS763844 kit is based on BMPR-1A antibody-BMPR-1A antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect BMPR-1A antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, BMPR-1A. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for BMPR-1A. It may not necessarily be applicable to this product.

NCBI GI #
41349437
NCBI GeneID
657
NCBI Accession #
NP_004320.2
UniProt Secondary Accession #
Q8NEN8; A8K6U9
UniProt Related Accession #
P36894
GenBank Nucleotide #
NM_004329.2
NCBI Official Full Name
bone morphogenetic protein receptor type-1A
NCBI Official Synonym Full Names
bone morphogenetic protein receptor type 1A
NCBI Official Symbol
BMPR1A
NCBI Official Synonym Symbols
ALK3; SKR5; CD292; ACVRLK3; 10q23del
UniProt Protein Name
Bone morphogenetic protein receptor type-1A
UniProt Synonym Protein Names
Activin receptor-like kinase 3; ALK-3; Serine/threonine-protein kinase receptor R5; SKR5; CD_antigen: CD292
UniProt Gene Name
BMPR1A
UniProt Synonym Gene Names
ACVRLK3; ALK3; BMP type-1A receptor; BMPR-1A; ALK-3; SKR5
UniProt Entry Name
BMR1A_HUMAN
NCBI Protein Information
bone morphogenetic protein receptor type-1A

NCBI Summary for BMPR-1A

The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. [provided by RefSeq, Jul 2008]
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UniProt Comments for BMPR-1A

BMPR1A: a serine/threonine-protein kinase receptor for Bone morphogenetic protein-2 and -4 (BMP-2 and BMP-4). Defects in BMPR1A are a cause of juvenile polyposis syndrome (JPS) and Cowden disease (CD), a cancer syndrome characterized by multiple hamartomas and by a high risk for breast, thyroid and endometriel cancers.

Protein type: Protein kinase, TKL; Protein kinase, Ser/Thr (receptor); Kinase, protein; Membrane protein, integral; EC 2.7.11.30; TKL group; STKR family; Type1 subfamily

Chromosomal Location of Human Ortholog: 10q22.3

Cellular Component: caveola; cell soma; dendrite; external side of plasma membrane; integral to membrane; plasma membrane

Molecular Function: ATP binding; glycoprotein binding; metal ion binding; protein binding; protein homodimerization activity; protein serine/threonine kinase activity; receptor signaling protein serine/threonine kinase activity; SMAD binding; transmembrane receptor protein serine/threonine kinase activity

Biological Process: BMP signaling pathway; chondrocyte differentiation; developmental growth; dorsal/ventral axis specification; ectoderm development; embryonic digit morphogenesis; embryonic organ development; hindlimb morphogenesis; immune response; in utero embryonic development; lateral mesoderm development; lung development; mesendoderm development; mesoderm formation; Mullerian duct regression; negative regulation of neurogenesis; neural crest cell development; neural plate mediolateral pattern formation; odontogenesis of dentine-containing teeth; palate development; paraxial mesoderm structural organization; pituitary gland development; positive regulation of bone mineralization; positive regulation of epithelial cell proliferation; positive regulation of mesenchymal cell proliferation; positive regulation of osteoblast differentiation; positive regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation; regulation of lateral mesodermal cell fate specification; somitogenesis; stem cell maintenance; transforming growth factor beta receptor signaling pathway

Disease: Juvenile Polyposis Syndrome; Polyposis Syndrome, Hereditary Mixed, 2
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Research Articles on BMPR-1A

1. Results support a novel role for miR-885-3p in tumor angiogenesis by targeting BMPR1A, which regulates a proangiogenic factor.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with BMPR-1A elisa kit

 Reference Product  PubMed Publications
 BMP2 elisa kit  >95 publications with BMPR-1A and BMP2
 BMP4 elisa kit  >82 publications with BMPR-1A and BMP4
 SMAD1 elisa kit  >80 publications with BMPR-1A and SMAD1
 BMP7 elisa kit  >40 publications with BMPR-1A and BMP7
 SMAD5 elisa kit  >32 publications with BMPR-1A and SMAD5
 BMP6 elisa kit  >18 publications with BMPR-1A and BMP6
 SMAD6 elisa kit  >14 publications with BMPR-1A and SMAD6
 GDF5 elisa kit  >13 publications with BMPR-1A and GDF5
 SMAD7 elisa kit  >10 publications with BMPR-1A and SMAD7
 ACVR2B elisa kit  >7 publications with BMPR-1A and ACVR2B

Pathways associated with BMPR-1A elisa kit

 Products by Pathway  Pathway Diagram
 BMP Signaling Pathway antibodies  BMP Signaling Pathway Diagram
 BMP Signaling Pathway antibodies  BMP Signaling Pathway Diagram
 BMP Signalling And Regulation Pathway antibodies  BMP Signalling And Regulation Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
 Heart Development Pathway antibodies  Heart Development Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Integrated Breast Cancer Pathway antibodies  Integrated Breast Cancer Pathway Diagram

Diseases associated with BMPR-1A elisa kit

 Disease Name  Pubmed Publications
 Juvenile polyposis syndrome Antibodies  >49 publications with BMPR-1A and Juvenile polyposis syndrome
 Heart Defects, Congenital Antibodies  >14 publications with BMPR-1A and Heart Defects, Congenital
 Chromosome Aberrations Antibodies  >14 publications with BMPR-1A and Chromosome Aberrations
 Vascular Diseases Antibodies  >13 publications with BMPR-1A and Vascular Diseases
 Breast Neoplasms Antibodies  >12 publications with BMPR-1A and Breast Neoplasms
 Craniofacial Abnormalities Antibodies  >12 publications with BMPR-1A and Craniofacial Abnormalities
 Hamartoma Syndrome, Multiple Antibodies  >11 publications with BMPR-1A and Hamartoma Syndrome, Multiple
 Hyperplasia Antibodies  >10 publications with BMPR-1A and Hyperplasia
 Female Urogenital Diseases Antibodies  >10 publications with BMPR-1A and Female Urogenital Diseases
 Abnormalities, Multiple Antibodies  >10 publications with BMPR-1A and Abnormalities, Multiple

Organs/Tissues associated with BMPR-1A elisa kit

 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >69 publications with BMPR-1A and Embryonic Tissue
 Muscle Antibodies  >51 publications with BMPR-1A and Muscle
 Heart Antibodies  >45 publications with BMPR-1A and Heart
 Vascular Antibodies  >35 publications with BMPR-1A and Vascular
 Brain Antibodies  >30 publications with BMPR-1A and Brain
 Connective Tissue Antibodies  >24 publications with BMPR-1A and Connective Tissue
 Intestine Antibodies  >21 publications with BMPR-1A and Intestine
 Ovary Antibodies  >20 publications with BMPR-1A and Ovary
 Liver Antibodies  >20 publications with BMPR-1A and Liver
 Skin Antibodies  >18 publications with BMPR-1A and Skin
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