Platelet-Derived Growth Factor Subunit A (PDGFA) ELISA Kit for Human

This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit A, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit B. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]

PDGFA: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFB. Belongs to the PDGF/VEGF growth factor family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Cytokine; Cell cycle regulation; Secreted

Chromosomal Location of Human Ortholog: 7p22

Cellular Component: cell surface; endoplasmic reticulum lumen; extracellular region; extracellular space; Golgi membrane; microvillus

Molecular Function: collagen binding; growth factor activity; platelet-derived growth factor binding; platelet-derived growth factor receptor binding; protein binding; protein heterodimerization activity; protein homodimerization activity

Biological Process: actin cytoskeleton organization and biogenesis; activation of MAPKK activity; alveolus development; angiogenesis; axon guidance; blood coagulation; cell activation; cell projection biogenesis; cell-cell signaling; epidermal growth factor receptor signaling pathway; extracellular matrix organization and biogenesis; fibroblast growth factor receptor signaling pathway; gut development; hair follicle development; innate immune response; inner ear development; insulin receptor signaling pathway; MAPKKK cascade; negative chemotaxis; negative regulation of phosphatidylinositol biosynthetic process; nerve growth factor receptor signaling pathway; organ morphogenesis; phosphoinositide-mediated signaling; platelet activation; platelet degranulation; platelet-derived growth factor receptor signaling pathway; positive regulation of cell division; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of DNA replication; positive regulation of fibroblast proliferation; positive regulation of MAP kinase activity; positive regulation of MAPKKK cascade; positive regulation of mesenchymal cell proliferation; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein amino acid autophosphorylation; positive regulation of protein kinase B signaling cascade; Ras protein signal transduction; regulation of actin cytoskeleton organization and biogenesis; regulation of peptidyl-tyrosine phosphorylation; regulation of smooth muscle cell migration; response to drug; response to estradiol stimulus; response to hypoxia; response to inorganic substance; response to retinoic acid; response to wounding; skin development; small GTPase mediated signal transduction; transforming growth factor beta receptor signaling pathway; vascular endothelial growth factor receptor signaling pathway; wound healing