Neutrophil Activating Protein 3 (NAP3) ELISA Kit for Rabbit

Function: Protects DNA from oxidative damage by sequestering intracellular Fe2+ ion and storing it in the form of Fe3+ oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe2+ ions, which prevents hydroxyl radical production by the Fenton reaction

By similarity. Required for the survival in the presence of oxidative stress. Dps is also a virulence factor that activates neutrophils, mast cells and monocytes. It binds to neutrophil-glycosphingolipids and to sulfated carbohydrates on mucin. It might have a role in the accumulation of neutrophils and monocytes at the site of infection. Induces superoxide anion generation, adhesion and chemotaxis of neutrophils, through a pertussis toxin-sensitive pathway involving MAP kinases. Ref.2 Ref.11 Ref.14 Ref.15 Ref.16 Ref.17

Catalytic activity: 2 Fe2+ + H2O2 + 2 H+ = 2 Fe3+ + 2 H2O.

Subunit structure: Homododecamer. The 12 subunits form a hollow sphere into which the mineral iron core of up to 500 Fe3+ can be deposited. Ref.13 Ref.18

Subcellular location: Cytoplasm.

Domain: 12 di-nuclear ferroxidase centers are located at the interfaces between subunits related by 2-fold symmetry axes

By similarity.

Miscellaneous: According to Ref.16, colocalizes with DNA but according to Ref.12 it does not interact with DNA.

Sequence similarities: Belongs to the Dps family.