Myocardin (MYOCD) ELISA Kit for Human

This gene encodes a nuclear protein, which is expressed in heart, aorta, and in smooth muscle cell-containing tissues. It functions as a transcriptional co-activator of serum response factor (SRF) and modulates expression of cardiac and smooth muscle-specific SRF-target genes, and thus may play a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]

myocardin: Smooth muscle cells (SM) and cardiac muscle cells- specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage (myogenesis). 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor; Cell development/differentiation

Chromosomal Location of Human Ortholog: 17p11.2

Cellular Component: nucleus

Molecular Function: histone acetyltransferase binding; histone deacetylase binding; protein binding; transcription factor binding

Biological Process: alveolus development; cardiac cell differentiation; cardiac muscle cell differentiation; gut development; negative regulation of cell proliferation; negative regulation of cyclin-dependent protein kinase activity; negative regulation of transcription from RNA polymerase II promoter; positive regulation of cell proliferation; positive regulation of DNA binding; positive regulation of smooth muscle cell differentiation; positive regulation of smooth muscle contraction; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of transforming growth factor beta receptor signaling pathway; regulation of cell growth by extracellular stimulus; regulation of histone acetylation; regulation of myoblast differentiation; regulation of smooth muscle cell differentiation; response to hypoxia; smooth muscle cell differentiation; transcription from RNA polymerase II promoter; urinary bladder development; uterus development; vasculogenesis; ventricular cardiac muscle cell differentiation