Hyaluronidase-2 (HYAL2) ELISA Kit for Human

This gene encodes a weak acid-active hyaluronidase. The encoded protein is similar in structure to other more active hyaluronidases. Hyaluronidases degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan and fragments of hyaluronan are thought to be involved in cell proliferation, migration and differentiation. Although it was previously thought to be a lysosomal hyaluronidase that is active at a pH below 4, the encoded protein is likely a GPI-anchored cell surface protein. This hyaluronidase serves as a receptor for the oncogenic virus Jaagsiekte sheep retrovirus. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. This gene encodes two alternatively spliced transcript variants which differ only in the 5' UTR.[provided by RefSeq, Mar 2010]

HYAL2: Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displays very low levels of activity. Associates with and negatively regulates MST1R. Belongs to the glycosyl hydrolase 56 family.

Protein type: Hydrolase; Membrane protein, GPI anchor; Glycan Metabolism - glycosaminoglycan degradation; EC 3.2.1.35

Chromosomal Location of Human Ortholog: 3p21.3

Cellular Component: anchored to external side of plasma membrane; anchored to plasma membrane; apical plasma membrane; cell surface; cytoplasm; cytoplasmic membrane-bound vesicle; cytoplasmic vesicle; cytosol; endocytic vesicle; endoplasmic reticulum; Golgi membrane; lipid raft; lysosome; microvillus; perinuclear region of cytoplasm; plasma membrane

Molecular Function: enzyme binding; hyaluronic acid binding; hyaluronoglucuronidase activity; hyalurononglucosaminidase activity; protein binding; receptor signaling protein tyrosine kinase inhibitor activity; receptor tyrosine kinase binding; transforming growth factor beta binding; viral receptor activity

Biological Process: carbohydrate metabolic process; cartilage development; defense response to virus; entry of virus into host cell; glycosaminoglycan catabolic process; glycosaminoglycan metabolic process; hemopoietic progenitor cell differentiation; hyaluronan catabolic process; hyaluronan metabolic process; kidney development; monocyte activation; multicellular organismal aging; negative regulation of cell growth; negative regulation of MAP kinase activity; negative regulation of protein kinase B signaling cascade; positive regulation of inflammatory response; positive regulation of protein import into nucleus; positive regulation of transcription from RNA polymerase II promoter; response to antibiotic; response to reactive oxygen species; response to virus; skeletal morphogenesis; transformation of host cell by virus; viral envelope fusion with host membrane