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Multidrug Resistance-Associated Protein 4 (ABCC4) ELISA Kit for Human

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS764500

Principle of the Assay||This kit was based on sandwich enzyme-linked immune-sorbent assay technology. Anti-Human ABCC4 antibody was pre-coated onto 96-well plates. And the biotin conjugated anti-Human ABCC4 antibody was used as detection antibodies. The… More details

$405 / 48-Strip-Wells +1 FREE 8GB USB

Product Documentation

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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Multidrug resistance-associated protein 4 (ABCC4), ELISA Kit
Full Product Name
Human Multidrug resistance-associated protein 4 ELISA Kit
Product Gene Name
ABCC4 elisa kit
Product Synonym Names
ABCC4 (Multidrug resistance-associated protein 4)/MRP4/MOAT-B/Multi-specific organic anion transporter B/ATP-binding cassette sub-family C member 4/MRP/cMOAT-related ABC transporter
Species Reactivity
Human
Assay Type
Sandwich ELISA, Double Antibody
Samples
Serum, Plasma, Cell Culture Supernatant, cell or tissue lysate, Other liquid samples
Detection Range
1.563-100ng/ml
Sensitivity
0.938ng/ml
Preparation and Storage
Store entire kit at 2-8C for short-term. For longer-term, please store the microplate & standard at -20C, while the remaining reagents can be stored at 2-8C
Molecular Weight
88,138 Da
OMIM
605250
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Typical Testing Data of ABCC4 elisa kit

Human ABCC4 ELISA Kit – Cat# MBS764500

Typical Standard Curve of ABCC4 elisa kit

Human ABCC4 ELISA Kit, Typical Standard Curve – Cat# MBS764500

Other Notes

Small volumes of ABCC4 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ABCC4 purchase

MBS764500 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Multidrug resistance-associated protein 4 (ABCC4) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing ABCC4. The ELISA analytical biochemical technique of the MBS764500 kit is based on ABCC4 antibody-ABCC4 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ABCC4 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ABCC4. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for ABCC4. It may not necessarily be applicable to this product.

NCBI GI #
685504974
NCBI GeneID
10257
NCBI Accession #
NP_001288758.1
UniProt Secondary Accession #
Q8IVZ4; Q8IZN6; Q8NEW8; Q9Y6J2; A9Z1Z7; B7Z3Q7
UniProt Related Accession #
O15439
GenBank Nucleotide #
NM_001301829.1
NCBI Official Full Name
multidrug resistance-associated protein 4 isoform 3
NCBI Official Synonym Full Names
ATP binding cassette subfamily C member 4
NCBI Official Symbol
ABCC4
NCBI Official Synonym Symbols
MRP4; MOATB; MOAT-B
UniProt Protein Name
Multidrug resistance-associated protein 4
UniProt Synonym Protein Names
ATP-binding cassette sub-family C member 4; MRP/cMOAT-related ABC transporter; Multi-specific organic anion transporter B; MOAT-B
Protein Family
ABC transporter C family
UniProt Gene Name
ABCC4
UniProt Synonym Gene Names
MRP4; MOAT-B
UniProt Entry Name
MRP4_HUMAN
NCBI Protein Information
multidrug resistance-associated protein 4

NCBI Summary for ABCC4

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This family member plays a role in cellular detoxification as a pump for its substrate, organic anions. It may also function in prostaglandin-mediated cAMP signaling in ciliogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]
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UniProt Comments for ABCC4

ABCC4: a widely-expressed multi-pass membrane protein. An organic anion pump involved in cellular detoxification. Widely expressed, with particularly high levels in prostate, but is barely detectable in liver.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family

Chromosomal Location of Human Ortholog: 13q32

Cellular Component: basolateral plasma membrane; integral to membrane; membrane; plasma membrane; platelet dense granule membrane

Molecular Function: 15-hydroxyprostaglandin dehydrogenase (NAD+) activity; ATP binding; ATPase activity, coupled to transmembrane movement of substances

Biological Process: blood coagulation; cilium biogenesis; platelet activation; platelet degranulation; prostaglandin secretion; transmembrane transport
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Research Articles on ABCC4

1. Data show the influence of ABCC2 and ABCC4 polymorphisms on tenofovir plasma concentrations in Thai HIV-infected patients

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with ABCC4 elisa kit

 Reference Product  PubMed Publications
 SLC22A6 elisa kit  >10 publications with ABCC4 and SLC22A6
 SLC22A8 elisa kit  >9 publications with ABCC4 and SLC22A8
 SLCO1B1 elisa kit  >8 publications with ABCC4 and SLCO1B1
 SLCO1A2 elisa kit  >4 publications with ABCC4 and SLCO1A2
 ABCG4 elisa kit  >1 publications with ABCC4 and ABCG4
 SNX27 elisa kit  >1 publications with ABCC4 and SNX27

Pathways associated with ABCC4 elisa kit

 Products by Pathway  Pathway Diagram
 ABC Transporters Pathway antibodies  ABC Transporters Pathway Diagram
 ABC Transporters Pathway antibodies  ABC Transporters Pathway Diagram
 ABC-family Proteins Mediated Transport Pathway antibodies  ABC-family Proteins Mediated Transport Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Drug Induction Of Bile Acid Pathway antibodies  Drug Induction Of Bile Acid Pathway Diagram
 Fluoropyrimidine Activity Pathway antibodies  Fluoropyrimidine Activity Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Platelet Activation, Signaling And Aggregation Pathway antibodies  Platelet Activation, Signaling And Aggregation Pathway Diagram
 Platelet Degranulation Pathway antibodies  Platelet Degranulation Pathway Diagram

Diseases associated with ABCC4 elisa kit

 Disease Name  Pubmed Publications
 Cholestasis Antibodies  >23 publications with ABCC4 and Cholestasis
 Liver Diseases Antibodies  >22 publications with ABCC4 and Liver Diseases
 Inflammation Antibodies  >20 publications with ABCC4 and Inflammation
 Disease Models, Animal Antibodies  >16 publications with ABCC4 and Disease Models, Animal
 Colorectal Neoplasms Antibodies  >12 publications with ABCC4 and Colorectal Neoplasms
 Fibrosis Antibodies  >12 publications with ABCC4 and Fibrosis
 Kidney Diseases Antibodies  >11 publications with ABCC4 and Kidney Diseases
 Necrosis Antibodies  >11 publications with ABCC4 and Necrosis
 Drug-Induced Liver Injury Antibodies  >10 publications with ABCC4 and Drug-Induced Liver Injury
 Breast Neoplasms Antibodies  >10 publications with ABCC4 and Breast Neoplasms

Organs/Tissues associated with ABCC4 elisa kit

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >122 publications with ABCC4 and Blood
 Liver Antibodies  >85 publications with ABCC4 and Liver
 Kidney Antibodies  >81 publications with ABCC4 and Kidney
 Brain Antibodies  >51 publications with ABCC4 and Brain
 Vascular Antibodies  >25 publications with ABCC4 and Vascular
 Lung Antibodies  >24 publications with ABCC4 and Lung
 Intestine Antibodies  >21 publications with ABCC4 and Intestine
 Muscle Antibodies  >17 publications with ABCC4 and Muscle
 Eye Antibodies  >11 publications with ABCC4 and Eye
 Prostate Antibodies  >10 publications with ABCC4 and Prostate
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