Cathepsin D (CTSD) ELISA Kit for Mouse

This gene encodes a member of the A1 family of peptidases. The encoded preproprotein is proteolytically processed to generate multiple protein products. These products include the cathepsin D light and heavy chains, which heterodimerize to form the mature enzyme. This enzyme exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimer's disease. [provided by RefSeq, Nov 2015]

CTSD: Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease. Consists of a light chain and a heavy chain. Belongs to the peptidase A1 family.

Protein type: EC 3.4.23.5; Autophagy; Motility/polarity/chemotaxis; Protease

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: extracellular matrix; extracellular region; extracellular space; lipid raft; lysosomal lumen; lysosome; melanosome

Molecular Function: aspartic-type endopeptidase activity; protein binding

Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; autophagy; collagen catabolic process; extracellular matrix disassembly; extracellular matrix organization and biogenesis; protein catabolic process; proteolysis

Disease: Ceroid Lipofuscinosis, Neuronal, 10