Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Epsilon (IKBKE) ELISA Kit for Human

IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines (Hutti et al., 2009 [PubMed 19481526]).[supplied by OMIM, Oct 2009]

IKKE: a oncogenic kinase of the IKK family. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Plays a pivotal role in coordinating the activation of IRF3 and NF-kappaB in the innate immune response. Its redistribution to PML nuclear bodies upon DNA damage is TOPORS-dependent. Is a breast cancer oncogene that exerts its oncogenic properties through cRel.

Protein type: Kinase, protein; Protein kinase, Other; EC 2.7.11.10; Protein kinase, Ser/Thr (non-receptor); Inhibitor; Other group; IKK family

Chromosomal Location of Human Ortholog: 1q32.1

Cellular Component: cytoplasm; cytosol; endosome membrane; mitochondrial membrane; nucleus; PML body

Molecular Function: ATP binding; IkappaB kinase activity; NF-kappaB-inducing kinase activity; protein binding; ubiquitin protein ligase binding

Biological Process: DNA damage response, signal transduction resulting in induction of apoptosis; I-kappaB phosphorylation; immune response; innate immune response; MyD88-independent toll-like receptor signaling pathway; negative regulation of interferon type I production; positive regulation of I-kappaB kinase/NF-kappaB cascade; protein amino acid phosphorylation; protein homooligomerization; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor signaling pathway