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Lysyl Oxidase Homolog 3 (LOXL3) ELISA Kit for Human

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS764709

Principle of the Assay||This kit was based on sandwich enzyme-linked immune-sorbent assay technology. Anti-LOXL3 antibody was pre-coated onto 96-well plates. And the biotin conjugated anti-LOXL3 antibody was used as detection antibodies. The standards, test… More details

$405 / 48-Strip-Wells +1 FREE 8GB USB

Product Documentation

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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Lysyl oxidase homolog 3 (LOXL3), ELISA Kit
Full Product Name
Human Lysyl oxidase homolog 3 ELISA Kit
Product Gene Name
LOXL3 elisa kit
Product Synonym Names
LOXL3 (Lysyl oxidase homolog 3)/LOL3/LOXL/lysyl oxidase-like 3/Lysyl oxidase-like protein 3
Species Reactivity
Human
Assay Type
Sandwich ELISA, Double Antibody
Samples
Serum, Plasma, Cell Culture Supernatant, cell or tissue lysate, Other liquid samples
Detection Range
0.469-30pmol/ml
Sensitivity
0.281pmol/ml
Preparation and Storage
Store entire kit at 2-8C for short-term. For longer-term, please store the microplate & standard at -20C, while the remaining reagents can be stored at 2-8C
Molecular Weight
67,445 Da
OMIM
607163
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Typical Testing Data of LOXL3 elisa kit

Human LOXL3 ELISA Kit – Cat# MBS764709

Typical Standard Curve of LOXL3 elisa kit

Human LOXL3 ELISA Kit, Typical Standard Curve – Cat# MBS764709

Other Notes

Small volumes of LOXL3 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LOXL3 purchase

MBS764709 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Lysyl oxidase homolog 3 (LOXL3) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing LOXL3. The ELISA analytical biochemical technique of the MBS764709 kit is based on LOXL3 antibody-LOXL3 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect LOXL3 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, LOXL3. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for LOXL3. It may not necessarily be applicable to this product.

NCBI GI #
14211943
NCBI GeneID
84695
NCBI Accession #
NP_115992.1
UniProt Secondary Accession #
Q2EHP2; Q6IPL7; Q96RS1; D6W5J1
UniProt Related Accession #
P58215
GenBank Nucleotide #
NM_032603.3
NCBI Official Full Name
lysyl oxidase homolog 3 isoform 1
NCBI Official Synonym Full Names
lysyl oxidase like 3
NCBI Official Symbol
LOXL3
NCBI Official Synonym Symbols
LOXL
UniProt Protein Name
Lysyl oxidase homolog 3
UniProt Synonym Protein Names
Lysyl oxidase-like protein 3
Protein Family
Lysyl oxidase
UniProt Gene Name
LOXL3
UniProt Synonym Gene Names
LOXL
UniProt Entry Name
LOXL3_HUMAN
NCBI Protein Information
lysyl oxidase homolog 3

NCBI Summary for LOXL3

This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. Alternatively spliced transcript variants of this gene have been reported but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
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UniProt Comments for LOXL3

LOXL3: a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. Alternatively spliced transcript variants of this gene have been reported but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]

Protein type: Secreted; Secreted, signal peptide; EC 1.4.3.-; Oxidoreductase

Chromosomal Location of Human Ortholog: 2p13

Cellular Component: cytoplasm; extracellular region; extracellular space; membrane; nucleus

Molecular Function: copper ion binding; protein binding; protein-lysine 6-oxidase activity; scavenger receptor activity

Biological Process: epithelial to mesenchymal transition; negative regulation of transcription, DNA-dependent; receptor-mediated endocytosis
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Research Articles on LOXL3

1. LOXL3 is a novel candidate gene for autosomal recessive Stickler syndrome.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with LOXL3 elisa kit

 Reference Product  PubMed Publications
 BMP1 elisa kit  >1 publications with LOXL3 and BMP1
 HTRA2 elisa kit  >1 publications with LOXL3 and HTRA2

Pathways associated with LOXL3 elisa kit

 Products by Pathway  Pathway Diagram
 Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway antibodies  Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway Diagram
 Collagen Formation Pathway antibodies  Collagen Formation Pathway Diagram
 Crosslinking Of Collagen Fibrils Pathway antibodies  Crosslinking Of Collagen Fibrils Pathway Diagram
 Elastic Fibre Formation Pathway antibodies  Elastic Fibre Formation Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram

Diseases associated with LOXL3 elisa kit

 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >3 publications with LOXL3 and Disease Models, Animal
 Vascular Diseases Antibodies  >3 publications with LOXL3 and Vascular Diseases
 Hypertension Antibodies  >3 publications with LOXL3 and Hypertension
 Nervous System Diseases Antibodies  >2 publications with LOXL3 and Nervous System Diseases
 Adenocarcinoma Antibodies  >2 publications with LOXL3 and Adenocarcinoma
 Blood Coagulation Disorders Antibodies  >1 publications with LOXL3 and Blood Coagulation Disorders
 Uterine Neoplasms Antibodies  >1 publications with LOXL3 and Uterine Neoplasms
 Inflammation Antibodies  >1 publications with LOXL3 and Inflammation
 Liver Neoplasms Antibodies  >1 publications with LOXL3 and Liver Neoplasms
 Neoplasm Metastasis Antibodies  >1 publications with LOXL3 and Neoplasm Metastasis

Organs/Tissues associated with LOXL3 elisa kit

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >6 publications with LOXL3 and Blood
 Testis Antibodies  >4 publications with LOXL3 and Testis
 Connective Tissue Antibodies  >4 publications with LOXL3 and Connective Tissue
 Eye Antibodies  >4 publications with LOXL3 and Eye
 Brain Antibodies  >2 publications with LOXL3 and Brain
 Mouth Antibodies  >2 publications with LOXL3 and Mouth
 Skin Antibodies  >2 publications with LOXL3 and Skin
 Pancreas Antibodies  >2 publications with LOXL3 and Pancreas
 Bone Antibodies  >2 publications with LOXL3 and Bone
 Prostate Antibodies  >1 publications with LOXL3 and Prostate
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