Chondroitin Sulfate Proteoglycan 4 (CSPG4) ELISA Kit for Mouse

NG2: a transmembrane chondrotin sulfate proteoglycan expressed on several types of immature progenitor cells and human malignant melanoma cells. Plays a role in cell proliferation and motility of endothelial cells during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. May regulate MPP16-dependent degradation and invasion of type I collagen participating to melanoma cells invasion properties. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through Cdc42, ACK1 and P130Cas. May activate FAK and ERK signaling cascades. PKC-alpha-mediated NG2 phosphorylation may be a key step for initiating cell polarization and motility.

Protein type: Membrane protein, integral; Cell adhesion

Cellular Component: apical plasma membrane; cell projection; cell surface; focal adhesion; integral to membrane; integral to plasma membrane; intracellular; plasma membrane

Molecular Function: collagen binding; protein kinase binding; signal transducer activity

Biological Process: activation of MAPK activity; angiogenesis; cell migration; cell proliferation; glial cell migration; inflammatory response; neuron remodeling; positive regulation of peptidyl-tyrosine phosphorylation; response to lithium ion; signal transduction; tissue remodeling; transmembrane receptor protein tyrosine kinase signaling pathway