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Pannexin-1 (PANX1) ELISA Kit for Human

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS764744

Principle of the Assay||This kit was based on sandwich enzyme-linked immune-sorbent assay technology. Anti-PANX1 antibody was pre-coated onto 96-well plates. And the biotin conjugated anti-PANX1 antibody was used as detection antibodies. The standards, test… More details

$405 / 48-Strip-Wells +1 FREE 8GB USB

Product Documentation

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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Pannexin-1 (PANX1), ELISA Kit
Full Product Name
Human Pannexin-1 ELISA Kit
Product Gene Name
PANX1 elisa kit
Product Synonym Names
PANX1 (Pannexin-1)/Innexin/MRS1/PX1/pannexin 1/UNQ2529
Species Reactivity
Human
Assay Type
Sandwich ELISA, Double Antibody
Samples
Serum, Plasma, Cell Culture Supernatant, cell or tissue lysate, Other liquid samples
Detection Range
0.156-10ng/ml
Sensitivity
0.094ng/ml
Preparation and Storage
Store entire kit at 2-8C for short-term. For longer-term, please store the microplate & standard at -20C, while the remaining reagents can be stored at 2-8C
Molecular Weight
47,635 Da
OMIM
608420
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Typical Testing Data of PANX1 elisa kit

Human PANX1 ELISA Kit – Cat# MBS764744

Typical Standard Curve of PANX1 elisa kit

Human PANX1 ELISA Kit, Typical Standard Curve – Cat# MBS764744

Other Notes

Small volumes of PANX1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PANX1 purchase

MBS764744 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Pannexin-1 (PANX1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing PANX1. The ELISA analytical biochemical technique of the MBS764744 kit is based on PANX1 antibody-PANX1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect PANX1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, PANX1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for PANX1. It may not necessarily be applicable to this product.

NCBI GI #
39995064
NCBI GeneID
24145
NCBI Accession #
NP_056183.2
UniProt Secondary Accession #
O75968; Q543A0; Q6UW26; Q96AM9; Q96L77; Q96RS5
UniProt Related Accession #
Q96RD7
GenBank Nucleotide #
NM_015368.3
NCBI Official Full Name
pannexin-1
NCBI Official Synonym Full Names
pannexin 1
NCBI Official Symbol
PANX1
NCBI Official Synonym Symbols
PX1; MRS1; UNQ2529
UniProt Protein Name
Pannexin-1
Protein Family
Pannexin
UniProt Gene Name
PANX1
UniProt Synonym Gene Names
MRS1
UniProt Entry Name
PANX1_HUMAN
NCBI Protein Information
pannexin-1

NCBI Summary for PANX1

The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 2 are abundantly expressed in central nerve system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 2 may form cell type-specific gap junctions with distinct properties. [provided by RefSeq, Jul 2008]
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UniProt Comments for PANX1

PANX1: Structural component of the gap junctions and the hemichannels. May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis. Belongs to the pannexin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Cell adhesion; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 11q21

Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; gap junction; integral to membrane; membrane; plasma membrane; protein complex

Molecular Function: actin filament binding; calcium channel activity; gap junction hemi-channel activity; leak channel activity; protease binding; protein heterodimerization activity; receptor binding

Biological Process: calcium ion transport; cation transport; cell-cell signaling; innate immune response; positive regulation of interleukin-1 alpha secretion; positive regulation of interleukin-1 beta secretion; response to ATP; synaptic transmission
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Research Articles on PANX1

1. These findings indicate that Panx1 participates in urothelial mechanotransduction and signaling by providing a direct pathway for mechanically-induced ATP release and by functionally interacting with P2X7Rs

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with PANX1 elisa kit

 Reference Product  PubMed Publications
 PANX2 elisa kit  >41 publications with PANX1 and PANX2
 CASP1 elisa kit  >19 publications with PANX1 and CASP1
 P2RX7 elisa kit  >16 publications with PANX1 and P2RX7
 NLRP3 elisa kit  >6 publications with PANX1 and NLRP3
 CASP7 elisa kit  >4 publications with PANX1 and CASP7
 SUGT1 elisa kit  >1 publications with PANX1 and SUGT1

Pathways associated with PANX1 elisa kit

 Products by Pathway  Pathway Diagram
 Electric Transmission Across Gap Junctions Pathway antibodies  Electric Transmission Across Gap Junctions Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Inflammasomes Pathway antibodies  Inflammasomes Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor (NLR) Signaling Pathways antibodies  Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor (NLR) Signaling Pathways Diagram
 The NLRP3 Inflammasome Pathway antibodies  The NLRP3 Inflammasome Pathway Diagram
 Transmission Across Electrical Synapses Pathway antibodies  Transmission Across Electrical Synapses Pathway Diagram

Diseases associated with PANX1 elisa kit

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >40 publications with PANX1 and Inflammation
 Disease Models, Animal Antibodies  >17 publications with PANX1 and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >12 publications with PANX1 and Cardiovascular Diseases
 Pain Antibodies  >9 publications with PANX1 and Pain
 Necrosis Antibodies  >8 publications with PANX1 and Necrosis
 Fibrosis Antibodies  >7 publications with PANX1 and Fibrosis
 Nerve Degeneration Antibodies  >6 publications with PANX1 and Nerve Degeneration
 Lung Diseases Antibodies  >4 publications with PANX1 and Lung Diseases
 Hypersensitivity Antibodies  >4 publications with PANX1 and Hypersensitivity
 Fatty Liver Antibodies  >3 publications with PANX1 and Fatty Liver

Organs/Tissues associated with PANX1 elisa kit

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >92 publications with PANX1 and Brain
 Muscle Antibodies  >29 publications with PANX1 and Muscle
 Eye Antibodies  >24 publications with PANX1 and Eye
 Vascular Antibodies  >20 publications with PANX1 and Vascular
 Embryonic Tissue Antibodies  >15 publications with PANX1 and Embryonic Tissue
 Skin Antibodies  >10 publications with PANX1 and Skin
 Kidney Antibodies  >8 publications with PANX1 and Kidney
 Lung Antibodies  >7 publications with PANX1 and Lung
 Liver Antibodies  >6 publications with PANX1 and Liver
 Bone Antibodies  >6 publications with PANX1 and Bone
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