• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

Connexin 40 (CX40) ELISA Kit for Rat

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS764781

Principle of the Assay||This kit was based on sandwich enzyme-linked immune-sorbent assay technology. anti-Rat CX40 antibody was pre-coated onto 96-well plates. And the biotin conjugated anti-Rat CX40 antibody was used as detection antibodies. The standards,… More details

$405 / 48-Strip-Wells +1 FREE 8GB USB

Product Documentation

PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Connexin 40 (CX40), ELISA Kit
Full Product Name
Rat Connexin 40 ELISA Kit
Product Gene Name
CX40 elisa kit
Product Synonym Names
CX40/ATFB11/GJA5/alpha 5; 40kD (connexin 40)/connexin-40/Connexin-40/Cx40/gap junction alpha-5 protein/gap junction protein; alpha 5; 40kDa/gap junction protein; alpha 5; 40kDa (connexin 40)/MGC11185
Species Reactivity
Rat
Assay Type
Sandwich ELISA, Double Antibody
Samples
Serum, Plasma, Cell Culture Supernatant, cell or tissue lysate, Other liquid samples
Detection Range
39.063-2500pg/ml
Sensitivity
23.438pg/ml
Preparation and Storage
Store entire kit at 2-8C for short-term. For longer-term, please store the microplate & standard at -20C, while the remaining reagents can be stored at 2-8C
Molecular Weight
40,380 Da
OMIM
108770
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Typical Testing Data of CX40 elisa kit

Rat CX40 ELISA Kit – Cat# MBS764781

Typical Standard Curve of CX40 elisa kit

Rat CX40 ELISA Kit, Typical Standard Curve – Cat# MBS764781

Other Notes

Small volumes of CX40 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CX40 purchase

MBS764781 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Connexin 40 (CX40) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing CX40. The ELISA analytical biochemical technique of the MBS764781 kit is based on CX40 antibody-CX40 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect CX40 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, CX40. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for CX40. It may not necessarily be applicable to this product.

NCBI GI #
1220303
NCBI GeneID
2702
NCBI Accession #
AAA91833.1
UniProt Secondary Accession #
Q5T3B6; Q5U0N6
UniProt Related Accession #
P36382
NCBI Official Full Name
connexin 40
NCBI Official Synonym Full Names
gap junction protein alpha 5
NCBI Official Symbol
GJA5
NCBI Official Synonym Symbols
CX40; ATFB11
UniProt Protein Name
Gap junction alpha-5 protein
UniProt Synonym Protein Names
Connexin-40; Cx40
Protein Family
Gap junction alpha-5 protein
UniProt Gene Name
GJA5
UniProt Synonym Gene Names
Cx40
UniProt Entry Name
CXA5_HUMAN
NCBI Protein Information
gap junction alpha-5 protein

NCBI Summary for CX40

This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Mutations in this gene may be associated with atrial fibrillation. Alternatively spliced transcript variants encoding the same isoform have been described. [provided by RefSeq, Jul 2008]
Show more

UniProt Comments for CX40

GJA5: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Defects in GJA5 are a cause of familial atrial standstill (FAS). Atrial standstill is an extremely rare arrhythmia, characterized by the absence of electrical and mechanical activity in the atria. Electrocardiographically, it is characterized by bradycardia, the absence of P waves, and a junctional narrow complex escape rhythm. Defects in GJA5 are the cause of familial atrial fibrillation type 11 (ATFB11). ATFB11 is a familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure. Belongs to the connexin family. Alpha-type (group II) subfamily.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Motility/polarity/chemotaxis; Channel, misc.

Chromosomal Location of Human Ortholog: 1q21.1

Cellular Component: cell projection; connexon complex; gap junction; integral to plasma membrane

Molecular Function: gap junction hemi-channel activity

Biological Process: angiogenesis; artery morphogenesis; embryonic heart tube development; embryonic limb morphogenesis; gap junction assembly; negative regulation of blood pressure; negative regulation of glomerular filtration; positive regulation of vasoconstriction; positive regulation of vasodilation; potassium ion transport; protein oligomerization; skeletal development; transmembrane transport

Disease: Atrial Fibrillation, Familial, 11; Atrial Standstill 1; Chromosome 1q21.1 Deletion Syndrome, 1.35-mb
Show more

Research Articles on CX40

1. Reduced Cx40 levels and heterogeneity of its distribution (relative to Cx43) are common in atrial fibrillation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CX40 elisa kit

 Reference Product  PubMed Publications
 GJA1 elisa kit  >4 publications with CX40 and GJA1
 TBX5 elisa kit  >2 publications with CX40 and TBX5
 GATA4 elisa kit  >2 publications with CX40 and GATA4

Pathways associated with CX40 elisa kit

 Products by Pathway  Pathway Diagram
 Calcium Regulation In The Cardiac Cell Pathway antibodies  Calcium Regulation In The Cardiac Cell Pathway Diagram
 Gap Junction Assembly Pathway antibodies  Gap Junction Assembly Pathway Diagram
 Gap Junction Trafficking Pathway antibodies  Gap Junction Trafficking Pathway Diagram
 Gap Junction Trafficking And Regulation Pathway antibodies  Gap Junction Trafficking And Regulation Pathway Diagram
 Membrane Trafficking Pathway antibodies  Membrane Trafficking Pathway Diagram
 Vesicle-mediated Transport Pathway antibodies  Vesicle-mediated Transport Pathway Diagram

Diseases associated with CX40 elisa kit

 Disease Name  Pubmed Publications
 Heart Diseases Antibodies  >24 publications with CX40 and Heart Diseases
 Arrhythmias, Cardiac Antibodies  >17 publications with CX40 and Arrhythmias, Cardiac
 Hypertrophy Antibodies  >2 publications with CX40 and Hypertrophy
 Cardiomyopathies Antibodies  >1 publications with CX40 and Cardiomyopathies
 Atherosclerosis Antibodies  >1 publications with CX40 and Atherosclerosis
 Hypertension Antibodies  >1 publications with CX40 and Hypertension

Organs/Tissues associated with CX40 elisa kit

 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >22 publications with CX40 and Heart
 Vascular Antibodies  >4 publications with CX40 and Vascular
 Embryonic Tissue Antibodies  >3 publications with CX40 and Embryonic Tissue
 Lung Antibodies  >3 publications with CX40 and Lung
 Ovary Antibodies  >2 publications with CX40 and Ovary
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000