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Interleukin-31 Receptor Subunit Alpha (IL31RA) ELISA Kit for Human

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS764872

Principle of the Assay||This kit was based on sandwich enzyme-linked immune-sorbent assay technology. Anti-IL31RA antibody was pre-coated onto 96-well plates. And the biotin conjugated anti-IL31RA antibody was used as detection antibodies. The standards, test… More details

$405 / 48-Strip-Wells +1 FREE 8GB USB

Product Documentation

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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Interleukin-31 receptor subunit alpha (IL31RA), ELISA Kit
Full Product Name
Human Interleukin-31 receptor subunit alpha ELISA Kit
Product Gene Name
IL31RA elisa kit
Product Synonym Names
IL31RA/CRL3/GLM-R/class I cytokine receptor/Cytokine receptor-like 3/GLMR/GP130 like receptor/Gp130-like monocyte receptor/hGLM-R/IL-31 receptor subunit alpha/IL-31R subunit alpha/IL-31R-alpha/interleukin 31 receptor A/soluble type I cytokine receptor CRL3
Species Reactivity
Human
Assay Type
Sandwich ELISA, Double Antibody
Samples
Serum, Plasma, Cell Culture Supernatant, cell or tissue lysate, Other liquid samples
Detection Range
15.625-1000pg/ml
Sensitivity
9.375pg/ml
Preparation and Storage
Store entire kit at 2-8C for short-term. For longer-term, please store the microplate & standard at -20C, while the remaining reagents can be stored at 2-8C
Molecular Weight
25,133 Da
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Typical Testing Data of IL31RA elisa kit

Human IL31RA ELISA Kit – Cat# MBS764872

Typical Standard Curve of IL31RA elisa kit

Human IL31RA ELISA Kit, Typical Standard Curve – Cat# MBS764872

Other Notes

Small volumes of IL31RA elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL31RA purchase

MBS764872 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Interleukin-31 receptor subunit alpha (IL31RA) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing IL31RA. The ELISA analytical biochemical technique of the MBS764872 kit is based on IL31RA antibody-IL31RA antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect IL31RA antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, IL31RA. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for IL31RA. It may not necessarily be applicable to this product.

NCBI GI #
225007641
NCBI GeneID
218624
NCBI Accession #
NP_647460.2
UniProt Secondary Accession #
Q6EAL6; Q6EAL7; Q6NZF0; Q8BSU3; Q8R501; E9QQ31
UniProt Related Accession #
Q8K5B1
GenBank Nucleotide #
NM_139299.2
NCBI Official Full Name
interleukin-31 receptor subunit alpha
NCBI Official Synonym Full Names
interleukin 31 receptor A
NCBI Official Symbol
Il31ra
NCBI Official Synonym Symbols
GPL; CRL3; Glmr; NR10; GLM-R
UniProt Protein Name
Interleukin-31 receptor subunit alpha
UniProt Synonym Protein Names
GLM-R; mGLM-R; Gp130-like monocyte receptor; Gp130-like receptor; Novel cytokine receptor 10; NR10; ZcytoR17
Protein Family
Interleukin-31 receptor
UniProt Gene Name
Il31ra
UniProt Synonym Gene Names
Glmr; IL-31 receptor subunit alpha; IL-31R subunit alpha; IL-31R-alpha; IL-31RA; mGLM-R; Gp130-like receptor; NR10
UniProt Entry Name
IL31R_MOUSE
NCBI Protein Information
interleukin-31 receptor subunit alpha

UniProt Comments for IL31RA

IL31RA: Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5. May function in skin immunity. Defects in IL31RA are the cause of amyloidosis primary localized cutaneous type 2 (PLCA2). PLCA2 is primary amyloidosis characterized by localized cutaneous amyloid deposition. This condition usually presents with itching (especially on the lower legs) and visible changes of skin hyperpigmentation and thickening that may be exacerbated by chronic scratching and rubbing. Primary localized cutaneous amyloidosis is often divided into macular and lichen subtypes although many affected individuals often show both variants coexisting. Lichen amyloidosis characteristically presents as a pruritic eruption of grouped hyperkeratotic papules with a predilection for the shins, calves, ankles and dorsa of feet and thighs. Papules may coalesce to form hyperkeratotic plaques that can resemble lichen planus, lichen simplex or nodular prurigo. Macular amyloidosis is characterized by small pigmented macules that may merge to produce macular hyperpigmentation, sometimes with a reticulate or rippled pattern. In macular and lichen amyloidosis, amyloid is deposited in the papillary dermis in association with grouped colloid bodies, thought to represent degenerate basal keratinocytes. The amyloid deposits probably reflect a combination of degenerate keratin filaments, serum amyloid P component, and deposition of immunoglobulins. Belongs to the type I cytokine receptor family. Type 2 subfamily. 12 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, cytokine

Cellular Component: external side of plasma membrane; integral to membrane; membrane; plasma membrane

Molecular Function: cytokine binding; hematopoietin/interferon-class (D200-domain) cytokine receptor activity

Biological Process: acute inflammatory response to antigenic stimulus; glandular epithelial cell differentiation; immune system process; positive regulation of cell proliferation
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Research Articles on IL31RA

1. IL-31 upregulates IL-31RA expression in DRG neuron cell bodies, and cutaneous-injected IL-31-induced itching is enhanced by DRG IL-31RA expression in mice

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with IL31RA elisa kit

 Reference Product  PubMed Publications
 Il31 elisa kit  >17 publications with IL31RA and Il31

Diseases associated with IL31RA elisa kit

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >17 publications with IL31RA and Inflammation
 Respiratory Tract Diseases Antibodies  >5 publications with IL31RA and Respiratory Tract Diseases
 Necrosis Antibodies  >2 publications with IL31RA and Necrosis
 Fibrosis Antibodies  >2 publications with IL31RA and Fibrosis
 Hyperplasia Antibodies  >1 publications with IL31RA and Hyperplasia
 Lung Neoplasms Antibodies  >1 publications with IL31RA and Lung Neoplasms

Organs/Tissues associated with IL31RA elisa kit

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >8 publications with IL31RA and Lung
 Muscle Antibodies  >1 publications with IL31RA and Muscle
 Embryonic Tissue Antibodies  >1 publications with IL31RA and Embryonic Tissue
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