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Gastricsin (PGC) ELISA Kit for Human

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS764921

Principle of the Assay||This kit was based on sandwich enzyme-linked immune-sorbent assay technology. Anti-PGC antibody was pre-coated onto 96-well plates. And the biotin conjugated anti-PGC antibody was used as detection antibodies. The standards, test… More details

$405 / 48-Strip-Wells +1 FREE 8GB USB

Product Documentation

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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Gastricsin (PGC), ELISA Kit
Full Product Name
Human Gastricsin ELISA Kit
Product Gene Name
PGC elisa kit
Product Synonym Names
PGC/Pepsinogen C/Gastricsin/PEPC/pepsin C/pepsinogen group II/PGII/preprogastricsin
Species Reactivity
Human
Assay Type
Sandwich ELISA, Double Antibody
Samples
Serum, Plasma, Cell Culture Supernatant, cell or tissue lysate, Other liquid samples
Detection Range
31.25-2000pg/ml
Sensitivity
18.75pg/ml
Preparation and Storage
Store entire kit at 2-8C for short-term. For longer-term, please store the microplate & standard at -20C, while the remaining reagents can be stored at 2-8C
Molecular Weight
34,208 Da
OMIM
169740
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Typical Testing Data of PGC elisa kit

Human PGC ELISA Kit – Cat# MBS764921

Typical Standard Curve of PGC elisa kit

Human PGC ELISA Kit, Typical Standard Curve – Cat# MBS764921

Other Notes

Small volumes of PGC elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PGC purchase

MBS764921 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Gastricsin (PGC) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing PGC. The ELISA analytical biochemical technique of the MBS764921 kit is based on PGC antibody-PGC antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect PGC antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, PGC. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for PGC. It may not necessarily be applicable to this product.

NCBI GI #
4505757
NCBI GeneID
5225
NCBI Accession #
NP_002621.1
UniProt Secondary Accession #
Q5T3D7; Q5T3D8; B4DVZ3
UniProt Related Accession #
P20142
GenBank Nucleotide #
NM_002630.3
NCBI Official Full Name
gastricsin isoform 1 preproprotein
NCBI Official Synonym Full Names
progastricsin (pepsinogen C)
NCBI Official Symbol
PGC
NCBI Official Synonym Symbols
PEPC; PGII
UniProt Protein Name
Gastricsin
UniProt Synonym Protein Names
Pepsinogen C
Protein Family
Gastricsin
UniProt Gene Name
PGC
UniProt Entry Name
PEPC_HUMAN
NCBI Protein Information
gastricsin

NCBI Summary for PGC

This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq, Oct 2009]
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UniProt Comments for PGC

PGC: Hydrolyzes a variety of proteins. Belongs to the peptidase A1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.23.3; Protease; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 6p21.1

Cellular Component: extracellular space

Molecular Function: aspartic-type endopeptidase activity

Biological Process: positive regulation of antibacterial peptide production; protein catabolic process
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Research Articles on PGC

1. The results highlight an important role of PGC rs3789210 and rs6939861 in altering susceptibility to atrophic gastritis and/or gastric cancer.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with PGC elisa kit

 Reference Product  PubMed Publications
 CDK9 elisa kit  >4 publications with PGC and CDK9
 CCNT1 elisa kit  >2 publications with PGC and CCNT1
 ESR1 elisa kit  >1 publications with PGC and ESR1

Diseases associated with PGC elisa kit

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >246 publications with PGC and Inflammation
 Fatty Liver Antibodies  >207 publications with PGC and Fatty Liver
 Liver Diseases Antibodies  >179 publications with PGC and Liver Diseases
 Heart Diseases Antibodies  >173 publications with PGC and Heart Diseases
 Atrophy Antibodies  >132 publications with PGC and Atrophy
 Necrosis Antibodies  >132 publications with PGC and Necrosis
 Hypertrophy Antibodies  >126 publications with PGC and Hypertrophy
 Kidney Diseases Antibodies  >91 publications with PGC and Kidney Diseases
 Neurologic Manifestations Antibodies  >90 publications with PGC and Neurologic Manifestations
 Weight Loss Antibodies  >71 publications with PGC and Weight Loss

Organs/Tissues associated with PGC elisa kit

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >602 publications with PGC and Liver
 Heart Antibodies  >412 publications with PGC and Heart
 Brain Antibodies  >364 publications with PGC and Brain
 Connective Tissue Antibodies  >243 publications with PGC and Connective Tissue
 Stomach Antibodies  >90 publications with PGC and Stomach
 Pancreas Antibodies  >55 publications with PGC and Pancreas
 Lung Antibodies  >51 publications with PGC and Lung
 Prostate Antibodies  >16 publications with PGC and Prostate
 Esophagus Antibodies  >6 publications with PGC and Esophagus
 Uncharacterized Tissue Antibodies  >1 publications with PGC and Uncharacterized Tissue
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