Poliovirus Receptor Related Protein 2 (PVRL2) ELISA Kit for Mouse

This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

nectin 2: Probable cell adhesion protein. Belongs to the nectin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: cell surface; cell-cell adherens junction; focal adhesion; integral to membrane; integral to plasma membrane; intercellular junction; plasma membrane; zonula adherens

Molecular Function: cell adhesion molecule binding; coreceptor activity; identical protein binding; protein binding; receptor binding

Biological Process: adhesion to host; cell recognition; heterophilic cell adhesion; homophilic cell adhesion; positive regulation of immunoglobulin mediated immune response; positive regulation of mast cell activation; positive regulation of natural killer cell mediated cytotoxicity; positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; regulation of immune response; regulation of virion penetration into host cell; spermatid development; susceptibility to natural killer cell mediated cytotoxicity; viral envelope fusion with host membrane; virion attachment, binding of host cell surface coreceptor