High Affinity Nerve Growth Factor Receptor (TrkA/NTRK1) ELISA Kit for Human

This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq, Jul 2008]

TrkA: a receptor tyrosine kinase of the Trk family. High affinity receptor for nerve growth factor, neurotrophin-3 and neurotrophin-4/5 but not brain- derived neurotrophic factor. Known substrates include Shc, PI-3K, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system. Two splice variant isoforms have been described.

Protein type: Kinase, protein; Oncoprotein; Protein kinase, TK; Membrane protein, integral; Protein kinase, tyrosine (receptor); EC 2.7.10.1; TK group; Trk family

Chromosomal Location of Human Ortholog: 1q21-q22

Cellular Component: axon; cell soma; cell surface; cytoplasmic vesicle; dendrite; early endosome; early endosome membrane; endosome; integral to plasma membrane; late endosome; late endosome membrane; plasma membrane; protein complex; receptor complex

Molecular Function: ATP binding; GPI-linked ephrin receptor activity; kinase binding; nerve growth factor binding; nerve growth factor receptor activity; neurotrophin binding; neurotrophin p75 receptor binding; protein binding; protein homodimerization activity; transmembrane receptor protein tyrosine kinase activity

Biological Process: activation of MAPKK activity; activation of NF-kappaB transcription factor; adenylate cyclase activation; aging; axon guidance; B cell differentiation; circadian rhythm; detection of mechanical stimulus involved in sensory perception of pain; detection of temperature stimulus involved in sensory perception of pain; ephrin receptor signaling pathway; learning and/or memory; mechanoreceptor differentiation; negative regulation of cell proliferation; negative regulation of neuron apoptosis; nerve growth factor receptor signaling pathway; olfactory nerve development; peptidyl-tyrosine phosphorylation; phosphoinositide-mediated signaling; phospholipase C activation; positive regulation of angiogenesis; positive regulation of GTPase activity; positive regulation of programmed cell death; positive regulation of protein amino acid phosphorylation; positive regulation of Ras protein signal transduction; positive regulation of synaptic transmission, glutamatergic; positive regulation of synaptogenesis; protein amino acid autophosphorylation; protein amino acid phosphorylation; Ras protein signal transduction; response to activity; response to axon injury; response to drug; response to electrical stimulus; response to ethanol; response to hydrostatic pressure; response to nutrient levels; response to radiation; Sertoli cell development; small GTPase mediated signal transduction; sympathetic nervous system development; transmembrane receptor protein tyrosine kinase signaling pathway

Disease: Insensitivity To Pain, Congenital, With Anhidrosis; Thyroid Carcinoma, Familial Medullary