Ubiquilin-1 (UBQLN1) ELISA Kit for Human

This gene encodes an ubiquitin-like protein (ubiquilin) that shares a high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to modulate accumulation of presenilin proteins, and it is found in lesions associated with Alzheimer's and Parkinson's disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

UBQLN1: Links CD47 to the cytoskeleton. Promotes the surface expression of GABA-A receptors. Promotes the accumulation of uncleaved PSEN1 and PSEN2 by stimulating their biosynthesis. Has no effect on PSEN1 and PSEN2 degradation. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 9q22|9q21.2-q21.3

Cellular Component: autophagic vacuole; cytoplasm; cytoplasmic vesicle; endoplasmic reticulum; nucleoplasm; perinuclear region of cytoplasm; plasma membrane; proteasome complex; protein complex

Molecular Function: identical protein binding; kinase binding; polyubiquitin binding; protein binding

Biological Process: ER-associated protein catabolic process; negative regulation of toll-like receptor 3 signaling pathway; positive regulation of protein ubiquitination; regulation of macroautophagy; regulation of protein ubiquitination