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Extracellular Calcium-Sensing Receptor (CASR) ELISA Kit for Human

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS765079

Principle of the Assay||This kit was based on sandwich enzyme-linked immune-sorbent assay technology. Anti-Human CASR antibody was pre-coated onto 96-well plates. And the biotin conjugated anti-Human CASR antibody was used as detection antibodies. The… More details

$405 / 48-Strip-Wells +1 FREE 8GB USB

Product Documentation

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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Extracellular calcium-sensing receptor (CASR), ELISA Kit
Full Product Name
Human Extracellular calcium-sensing receptor ELISA Kit
Product Gene Name
CASR elisa kit
Product Synonym Names
CASR/Extracellular calcium-sensing receptor/CaSR/Parathyroid cell calcium-sensing receptor/PCaR1/GPRC2A/CAR/EIG8/FHH/FIH/HHC; HHC1/NSHPT
Species Reactivity
Human
Assay Type
Sandwich ELISA, Double Antibody
Samples
Serum, Plasma, Cell Culture Supernatant, cell or tissue lysate, Other liquid samples
Detection Range
0.313-20ng/ml
Sensitivity
0.188ng/ml
Preparation and Storage
Store entire kit at 2-8C for short-term. For longer-term, please store the microplate & standard at -20C, while the remaining reagents can be stored at 2-8C
Molecular Weight
121,772 Da
OMIM
145980
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Typical Testing Data of CASR elisa kit

Human CASR ELISA Kit – Cat# MBS765079

Typical Standard Curve of CASR elisa kit

Human CASR ELISA Kit, Typical Standard Curve – Cat# MBS765079

Other Notes

Small volumes of CASR elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CASR purchase

MBS765079 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Extracellular calcium-sensing receptor (CASR) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing CASR. The ELISA analytical biochemical technique of the MBS765079 kit is based on CASR antibody-CASR antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect CASR antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, CASR. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for CASR. It may not necessarily be applicable to this product.

NCBI GI #
37577159
NCBI GeneID
846
NCBI Accession #
NP_000379.2
UniProt Secondary Accession #
Q13912; Q16108; Q16109; Q16110; Q16379; Q2M1T0; Q4PJ19
UniProt Related Accession #
P41180
GenBank Nucleotide #
NM_000388.3
NCBI Official Full Name
extracellular calcium-sensing receptor isoform 2
NCBI Official Synonym Full Names
calcium sensing receptor
NCBI Official Symbol
CASR
NCBI Official Synonym Symbols
CAR; FHH; FIH; HHC; EIG8; HHC1; NSHPT; PCAR1; GPRC2A; HYPOC1
UniProt Protein Name
Extracellular calcium-sensing receptor
UniProt Synonym Protein Names
Parathyroid cell calcium-sensing receptor 1; PCaR1
Protein Family
Extracellular calcium-sensing receptor
UniProt Gene Name
CASR
UniProt Synonym Gene Names
GPRC2A; PCAR1; CaSR; PCaR1
UniProt Entry Name
CASR_HUMAN
NCBI Protein Information
extracellular calcium-sensing receptor

NCBI Summary for CASR

The protein encoded by this gene is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism. [provided by RefSeq, Jul 2008]
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UniProt Comments for CASR

CaR: a G-protein coupled receptor that activates a phosphatidylinositol-calcium second messenger system. Functions as a calcium sensor for parathyroid and kidney to determine the extracellular calcium concentration and thus helps to maintain a stable calcium concentration. Two alternatively-spliced isoforms have been described.

Protein type: GPCR, family 3; Motility/polarity/chemotaxis; Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 3q13

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity; phosphoinositide phospholipase C activity; protein binding

Biological Process: anatomical structure morphogenesis; cellular calcium ion homeostasis; chemosensory behavior; detection of calcium ion; G-protein coupled receptor protein signaling pathway; ossification

Disease: Epilepsy, Idiopathic Generalized, Susceptibility To, 8; Hyperparathyroidism, Neonatal Severe; Hypocalcemia, Autosomal Dominant 1; Hypocalciuric Hypercalcemia, Familial, Type I
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Research Articles on CASR

1. These studies have revealed new insights into the CaSR signalling pathway and its role in regulating extracellular homeostasis and the etiology of parathyroid diseases--{REVIEW}

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CASR elisa kit

 Reference Product  PubMed Publications
 PTH elisa kit  >259 publications with CASR and PTH
 APP elisa kit  >2 publications with CASR and APP
 SST elisa kit  >1 publications with CASR and SST
 AGT elisa kit  >1 publications with CASR and AGT
 AVP elisa kit  >1 publications with CASR and AVP
 NPSR1 elisa kit  >1 publications with CASR and NPSR1

Pathways associated with CASR elisa kit

 Products by Pathway  Pathway Diagram
 Class C/3 (Metabotropic Glutamate/pheromone Receptors) Pathway antibodies  Class C/3 (Metabotropic Glutamate/pheromone Receptors) Pathway Diagram
 E-cadherin Signaling In Keratinocytes Pathway antibodies  E-cadherin Signaling In Keratinocytes Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class C Metabotropic Glutamate, Pheromone Pathway antibodies  GPCRs, Class C Metabotropic Glutamate, Pheromone Pathway Diagram
 Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies  Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram

Diseases associated with CASR elisa kit

 Disease Name  Pubmed Publications
 Hyperparathyroidism Antibodies  >257 publications with CASR and Hyperparathyroidism
 Hypercalcemia Antibodies  >220 publications with CASR and Hypercalcemia
 Hypocalcemia Antibodies  >134 publications with CASR and Hypocalcemia
 Kidney Diseases Antibodies  >107 publications with CASR and Kidney Diseases
 Hypoparathyroidism Antibodies  >85 publications with CASR and Hypoparathyroidism
 Hypertension Antibodies  >49 publications with CASR and Hypertension
 Cardiovascular Diseases Antibodies  >49 publications with CASR and Cardiovascular Diseases
 Inflammation Antibodies  >33 publications with CASR and Inflammation
 Hypocalciuric hypercalcemia, familial, type 1 Antibodies  >33 publications with CASR and Hypocalciuric hypercalcemia, familial, type 1
 Brain Diseases Antibodies  >27 publications with CASR and Brain Diseases

Organs/Tissues associated with CASR elisa kit

 Organ/Tissue Name  Pubmed Publications
 Parathyroid Antibodies  >429 publications with CASR and Parathyroid
 Kidney Antibodies  >263 publications with CASR and Kidney
 Liver Antibodies  >37 publications with CASR and Liver
 Pancreas Antibodies  >21 publications with CASR and Pancreas
 Eye Antibodies  >1 publications with CASR and Eye
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