B-Cell Lymphoma/Leukemia 10 (BCL10) ELISA Kit for Rat

Bcl-10: a ubiquitous pro-apoptotic protein that promotes pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Self-associates via CARD-CARD interactions; forms a tight complex with MALT1. Interacts with other CARD-proteins such as CARD9, CARD10, CARD11 and CARD14. Binds caspase-9 with its C-terminal domain. Interacts with TRAF2 and BIRC2/c-IAP2. Defects in BCL10 are involved in various types of cancer.

Protein type: Apoptosis; Transcription, coactivator/corepressor; Tumor suppressor

Cellular Component: cytoplasm; cytoplasmic microtubule; cytosol; immunological synapse; lipid raft; lipopolysaccharide receptor complex; lysosome; membrane; nucleus; perinuclear region of cytoplasm; protein complex; T cell receptor complex

Molecular Function: caspase activator activity; enzyme binding; kinase activator activity; kinase binding; NF-kappaB binding; protease binding; protein binding; protein C-terminus binding; protein heterodimerization activity; protein homodimerization activity; protein kinase B binding; protein kinase binding; protein self-association; transcription coactivator activity; transcription factor binding; ubiquitin binding; ubiquitin protein ligase binding

Biological Process: activation of JNK activity; activation of NF-kappaB transcription factor; adaptive immune response; apoptosis; B cell apoptosis; caspase activation; cell death; cellular defense response; I-kappaB kinase/NF-kappaB cascade; immune system process; immunoglobulin mediated immune response; mast cell activation; negative regulation of mature B cell apoptosis; neural tube closure; positive regulation of apoptosis; positive regulation of caspase activity; positive regulation of interleukin-8 biosynthetic process; positive regulation of phosphorylation; positive regulation of protein ubiquitination; positive regulation of T cell activation; positive regulation of transcription, DNA-dependent; protein heterooligomerization; protein homooligomerization; protein oligomerization; regulation of apoptosis; regulation of T cell receptor signaling pathway; response to food; response to fungus; T cell receptor signaling pathway