Proliferation-Associated Protein 2g4 (PA2G4) ELISA Kit for Human

Name: Human PA2G4 ELISA Kit; Proliferation-Associated Protein 2g4; MyBioSource
Brand: MyBioSource
SKU: MBS765908
Price: 405 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS765908

Principle of the Assay: This kit was based on sandwich enzyme-linked immune-sorbent assay technology. Capture antibody was pre-coated onto 96-well plates. And the biotin conjugated antibody was used as detection antibodies. The standards, test samples and… More details

$405 / 48-Strip-Wells +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

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Product Overview

Online Datasheet in PDF

Product Name

Proliferation-associated protein 2G4 (PA2G4), ELISA Kit

Full Product Name

Human Proliferation-associated protein 2G4 ELISA Kit

Product Gene Name

PA2G4 elisa kit

Product Synonym Names

PA2G4 (Proliferation Associated Protein 2G4)/EBP1/HG4-1/Cell cycle protein p38-2G4 homolog/ErbB-3 binding protein 1/ErbB3-binding protein 1/ErbB3-binding protein Ebp1/p38-2G4/proliferation-associated 2G4; 38kD/proliferation-associated protein 2G4

Species Reactivity

Human

Assay Type

Sandwich

Samples

Serum, plasma, tissue homogenates and other biological fluids

Detection Range

0.313-20ng/ml

Sensitivity

0.188ng/ml

Specificity

This assay has high sensitivity and excellent specificity for detection of PA2G4. No significant cross-reactivity or interference between PA2G4 and analogues was observed.

Preparation and Storage

Store entire kit at 2-8C for short-term. For longer-term, please store the microplate & standard at -20C, while the remaining reagents can be stored at 2-8C

Inter-assay Precision

CV<10%

Intra-assay Precision

CV<8%

Molecular Weight

38,059 Da

OMIM

602145

ISO Certification

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Other Notes

Small volumes of PA2G4 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PA2G4 purchase

MBS765908 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Proliferation-associated protein 2G4 (PA2G4) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing PA2G4. The ELISA analytical biochemical technique of the MBS765908 kit is based on PA2G4 antibody-PA2G4 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect PA2G4 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, PA2G4. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for PA2G4. It may not necessarily be applicable to this product.

NCBI GI #

124494254

NCBI GeneID

5036

NCBI Accession #

NP_006182.2

UniProt Secondary Accession #

O43846; Q9UM59

UniProt Related Accession #

Q9UQ80

GenBank Nucleotide #

NM_006191.2

NCBI Official Full Name

proliferation-associated protein 2G4

NCBI Official Synonym Full Names

proliferation-associated 2G4

NCBI Official Symbol

PA2G4

NCBI Official Synonym Symbols

EBP1; HG4-1; p38-2G4

UniProt Protein Name

Proliferation-associated protein 2G4

UniProt Synonym Protein Names

Cell cycle protein p38-2G4 homolog; hG4-1; ErbB3-binding protein 1

Protein Family

Proliferation-associated protein

UniProt Gene Name

PA2G4

UniProt Synonym Gene Names

EBP1; hG4-1

UniProt Entry Name

PA2G4_HUMAN

NCBI Protein Information

proliferation-associated protein 2G4

NCBI Summary for PA2G4

This gene encodes an RNA-binding protein that is involved in growth regulation. This protein is present in pre-ribosomal ribonucleoprotein complexes and may be involved in ribosome assembly and the regulation of intermediate and late steps of rRNA processing. This protein can interact with the cytoplasmic domain of the ErbB3 receptor and may contribute to transducing growth regulatory signals. This protein is also a transcriptional co-repressor of androgen receptor-regulated genes and other cell cycle regulatory genes through its interactions with histone deacetylases. This protein has been implicated in growth inhibition and the induction of differentiation of human cancer cells. Six pseudogenes, located on chromosomes 3, 6, 9, 18, 20 and X, have been identified. [provided by RefSeq, Jul 2008]

UniProt Comments for PA2G4

Ebp1: May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site). Belongs to the peptidase M24 family.

Protein type: Nuclear receptor co-regulator; Nucleolus; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 12q13.2

Cellular Component: cytoplasm; membrane; nucleolus; nucleoplasm; nucleus; ribonucleoprotein complex

Molecular Function: DNA binding; protein binding; transcription factor activity; ubiquitin protein ligase binding

Biological Process: cell cycle arrest; cell proliferation; negative regulation of apoptosis; negative regulation of transcription, DNA-dependent; positive regulation of cell differentiation; regulation of translation; rRNA processing; transcription, DNA-dependent

Research Articles on PA2G4

1. Ebp1 functionality is independent from heat-shock-protein-regulated progression networks in prostate cancer.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with PA2G4 elisa kit

Reference Product	PubMed Publications
ERBB3 elisa kit	>41 publications with PA2G4 and ERBB3

Pathways associated with PA2G4 elisa kit

Products by Pathway	Pathway Diagram
Coregulation Of Androgen Receptor Activity Pathway antibodies	Coregulation Of Androgen Receptor Activity Pathway Diagram

Diseases associated with PA2G4 elisa kit

Disease Name	Pubmed Publications
Breast Neoplasms Antibodies	>12 publications with PA2G4 and Breast Neoplasms
Disease Progression Antibodies	>9 publications with PA2G4 and Disease Progression
Adenocarcinoma Antibodies	>5 publications with PA2G4 and Adenocarcinoma
Disease Models, Animal Antibodies	>4 publications with PA2G4 and Disease Models, Animal
Nervous System Diseases Antibodies	>3 publications with PA2G4 and Nervous System Diseases
Neoplasms, Experimental Antibodies	>3 publications with PA2G4 and Neoplasms, Experimental
Inflammation Antibodies	>3 publications with PA2G4 and Inflammation
Cell Transformation, Neoplastic Antibodies	>2 publications with PA2G4 and Cell Transformation, Neoplastic
Carcinoma, Hepatocellular Antibodies	>2 publications with PA2G4 and Carcinoma, Hepatocellular
Lung Diseases Antibodies	>2 publications with PA2G4 and Lung Diseases

Organs/Tissues associated with PA2G4 elisa kit

Organ/Tissue Name	Pubmed Publications
Prostate Antibodies	>15 publications with PA2G4 and Prostate
Blood Antibodies	>7 publications with PA2G4 and Blood
Salivary Gland Antibodies	>4 publications with PA2G4 and Salivary Gland
Mouth Antibodies	>4 publications with PA2G4 and Mouth
Muscle Antibodies	>4 publications with PA2G4 and Muscle
Brain Antibodies	>4 publications with PA2G4 and Brain
Lung Antibodies	>3 publications with PA2G4 and Lung
Intestine Antibodies	>2 publications with PA2G4 and Intestine
Embryonic Tissue Antibodies	>2 publications with PA2G4 and Embryonic Tissue
Liver Antibodies	>2 publications with PA2G4 and Liver