Corticoliberin (CRH) ELISA Kit for Mouse

This gene encodes a member of the corticotropin-releasing factor family. The encoded preproprotein is proteolytically processed to generate the mature neuropeptide hormone. In response to stress, this hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus, binds to corticotropin releasing hormone receptors and stimulates the release of adrenocorticotropic hormone from the pituitary gland. Marked reduction in this protein has been observed in association with Alzheimer's disease. Autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes, and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturition. [provided by RefSeq, Nov 2015]

CRH: This hormone from hypothalamus regulates the release of corticotropin from pituitary gland. Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 8q13

Cellular Component: cytoplasm; extracellular region; extracellular space; perikaryon

Molecular Function: corticotropin-releasing hormone receptor 1 binding; corticotropin-releasing hormone receptor 2 binding; hormone activity; neuropeptide hormone activity; protein binding; receptor binding

Biological Process: adrenal gland development; associative learning; diterpenoid metabolic process; female pregnancy; glucocorticoid biosynthetic process; hypothalamus development; induction of apoptosis by hormones; inflammatory response; ion homeostasis; learning and/or memory; lung development; negative regulation of blood pressure; negative regulation of circadian sleep/wake cycle, REM sleep; negative regulation of epinephrine secretion; negative regulation of luteinizing hormone secretion; parturition; positive regulation of adrenocorticotropic hormone secretion; positive regulation of cAMP biosynthetic process; positive regulation of cell proliferation; positive regulation of cortisol secretion; positive regulation of protein amino acid phosphorylation; regulation of serotonin secretion; response to corticosterone stimulus; response to drug; response to estrogen stimulus; response to ethanol; response to ether; response to pain; signal transduction; synaptic transmission; synaptic transmission, dopaminergic

Disease: Acth Deficiency, Isolated