Protein Kinase C Zeta (PKCzeta) ELISA Kit for Human

Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

PKCZ: an AGC kinase of the PKC family. An atypical PKC: its activity is not regulated by Ca2+, PS, DAG or phorbol esters. Constitutively active.

Protein type: Kinase, protein; EC 2.7.11.13; Protein kinase, Ser/Thr (non-receptor); Protein kinase, AGC; AGC group; PKC family; Iota subfamily

Chromosomal Location of Human Ortholog: 1p36.33-p36.2

Cellular Component: apical cortex; apical plasma membrane; axon hillock; cell junction; cytoplasm; cytosol; endosome; filamentous actin; intercellular junction; leading edge; lipid raft; membrane; microtubule organizing center; nuclear envelope; nuclear matrix; perinuclear region of cytoplasm; plasma membrane; tight junction; vesicle

Molecular Function: ATP binding; insulin receptor substrate binding; metal ion binding; phospholipase binding; potassium channel regulator activity; protein binding; protein domain specific binding; protein kinase activity; protein kinase binding; protein kinase C activity; protein serine/threonine kinase activity

Biological Process: actin cytoskeleton reorganization; activation of NF-kappaB transcription factor; activation of protein kinase B; blood coagulation; cell migration; establishment of cell polarity; inflammatory response; insulin receptor signaling pathway; long-term memory; membrane depolarization; membrane hyperpolarization; microtubule cytoskeleton organization and biogenesis; negative regulation of apoptosis; negative regulation of hydrolase activity; negative regulation of insulin receptor signaling pathway; negative regulation of peptidyl-tyrosine phosphorylation; negative regulation of protein complex assembly; peptidyl-serine phosphorylation; phospholipase D activation; platelet activation; positive regulation of cell proliferation; positive regulation of cell-matrix adhesion; positive regulation of glucose import; positive regulation of insulin receptor signaling pathway; positive regulation of interleukin-4 production; positive regulation of T-helper 2 cell differentiation; protein amino acid phosphorylation; protein heterooligomerization; signal transduction; transforming growth factor beta receptor signaling pathway; vascular endothelial growth factor receptor signaling pathway; vesicle transport along microtubule