ABCA7 Antibody – Rabbit Polyclonal

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This full transporter has been detected predominantly in myelo-lymphatic tissues with the highest expression in peripheral leukocytes, thymus, spleen, and bone marrow. The function of this protein is not yet known; however, the expression pattern suggests a role in lipid homeostasis in cells of the immune system. [provided by RefSeq, Jul 2008]

ABCA7: Plays a role in phagocytosis by macrophages of apoptotic cells. Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells. May also mediate cholesterol efflux. May regulate cellular ceramide homeostasis during keratinocytes differentiation. Belongs to the ABC transporter superfamily. ABCA family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transporter, ABC family; Transporter; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: apical plasma membrane; ATP-binding cassette (ABC) transporter complex; cell junction; cell surface; early endosome membrane; Golgi apparatus; Golgi membrane; integral to membrane; intracellular membrane-bound organelle; phagocytic cup; plasma membrane

Molecular Function: apolipoprotein A-I receptor activity; ATP binding; ATPase activity; ATPase activity, coupled to transmembrane movement of substances; phospholipid transporter activity; transporter activity

Biological Process: cholesterol efflux; memory; negative regulation of amyloid precursor protein biosynthetic process; negative regulation of ATPase activity; peptide cross-linking; phagocytosis; phospholipid efflux; phospholipid scrambling; positive regulation of ATPase activity; positive regulation of phagocytosis; transmembrane transport