• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

ADRA2B Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS766411

MBS766411 is an antibody targeting ADRA2B. Also known as ADRA2B-Specific Rabbit Polyclonal. Reactive in Human, Mouse, Rat. Host: Rabbit. More details

DISCONTINUED
Click here to view our similar product(s) OR click here to contact our technical support team for suitable replacement.
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Product Name
ADRA2B, Polyclonal Antibody
Full Product Name
ADRA2B-Specific Rabbit Polyclonal
Product Gene Name
anti-ADRA2B antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Purity/Purification
>=95% as determined by SDS-PAGE
Immunogen Affinity Purified
Preparation and Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)
Molecular Weight
49,566 Da
OMIM
104260
Immunogen
Adrenergic, alpha-2B-, receptor
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-ADRA2B antibody
ELISA (EIA), Western Blot (WB)

Immunohistochemistry (IHC) of anti-ADRA2B antibody

Immunohistochemistry of paraffin-embedded mouse brain tissue slide using MBS766411 (ADRA2B-Specific Antibody) at dilution of 1:100 . heat mediated antigen retrieved with Tris-EDTA buffer (pH9) .
Rabbit Anti-ADRA2B Polyclonal Antibody – Cat# MBS766411

Western Blot (WB) of anti-ADRA2B antibody

mouse brain tissue were subjected to SDS PAGE followed by western blot with MBS766411 (ADRA2B-Specific antibody) at dilution of 1:100
Rabbit Anti-ADRA2B Polyclonal Antibody, Western Blot (WB) – Cat# MBS766411

Other Notes

Small volumes of anti-ADRA2B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ADRA2B. It may not necessarily be applicable to this product.

NCBI GI #
33598960
NCBI GeneID
151
NCBI Accession #
NP_000673.2
UniProt Secondary Accession #
Q4TUH9; Q53RF2; Q9BZK0
UniProt Related Accession #
P18089
GenBank Nucleotide #
NM_000682.6
NCBI Official Full Name
alpha-2B adrenergic receptor
NCBI Official Synonym Full Names
adrenoceptor alpha 2B
NCBI Official Symbol
ADRA2B
NCBI Official Synonym Symbols
FAME2; ADRA2L1; ADRARL1; ADRA2RL1; ALPHA2BAR; alpha-2BAR
UniProt Protein Name
Alpha-2B adrenergic receptor
UniProt Synonym Protein Names
Alpha-2 adrenergic receptor subtype C2; Alpha-2B adrenoreceptor; Alpha-2B adrenoceptor; Alpha-2BAR
Protein Family
Alpha-2B adrenergic receptor
UniProt Gene Name
ADRA2B
UniProt Synonym Gene Names
ADRA2L1; ADRA2RL1; Alpha-2B adrenoceptor; Alpha-2BAR
UniProt Entry Name
ADA2B_HUMAN
NCBI Protein Information
alpha-2B adrenergic receptor

NCBI Summary for ADRA2B

This intronless gene encodes a seven-pass transmembrane protein. This protein is a member of a subfamily of G protein-coupled receptors that regulate neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. [provided by RefSeq, Apr 2014]

UniProt Comments for ADRA2B

ADRA2B: Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2B sub-subfamily.

Protein type: Receptor, GPCR; Membrane protein, integral; GPCR, family 1; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 2q11.1

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: alpha2-adrenergic receptor activity; epinephrine binding; protein binding

Biological Process: activation of protein kinase B; cell-cell signaling; G-protein coupled receptor protein signaling pathway; negative regulation of epinephrine secretion; platelet activation; positive regulation of neuron differentiation; regulation of smooth muscle contraction; regulation of vasoconstriction

Disease: Epilepsy, Familial Adult Myoclonic, 2
Show more

Research Articles on ADRA2B

1. Common polymorphisms in the ADRA2B gene are not associated with orthostatic hypotension risk in Chinese.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ADRA2B antibody

 Reference Product  PubMed Publications
 CNR1 antibody  >1 publications with ADRA2B and CNR1

Pathways associated with anti-ADRA2B antibody

 Products by Pathway  Pathway Diagram
 Adrenaline Signalling Through Alpha-2 Adrenergic Receptor Pathway antibodies  Adrenaline Signalling Through Alpha-2 Adrenergic Receptor Pathway Diagram
 Adrenoceptors Pathway antibodies  Adrenoceptors Pathway Diagram
 Amine Ligand-binding Receptors Pathway antibodies  Amine Ligand-binding Receptors Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 G Alpha (z) Signalling Events Pathway antibodies  G Alpha (z) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram

Diseases associated with anti-ADRA2B antibody

 Disease Name  Pubmed Publications
 Hypertension Antibodies  >26 publications with ADRA2B and Hypertension
 Heart Diseases Antibodies  >12 publications with ADRA2B and Heart Diseases
 Pain Antibodies  >3 publications with ADRA2B and Pain
 Hypotension Antibodies  >3 publications with ADRA2B and Hypotension
 Myocardial Infarction Antibodies  >3 publications with ADRA2B and Myocardial Infarction
 Weight Gain Antibodies  >3 publications with ADRA2B and Weight Gain
 Hypertrophy Antibodies  >3 publications with ADRA2B and Hypertrophy
 Arrhythmias, Cardiac Antibodies  >3 publications with ADRA2B and Arrhythmias, Cardiac
 Weight Loss Antibodies  >2 publications with ADRA2B and Weight Loss
 Learning Disorders Antibodies  >2 publications with ADRA2B and Learning Disorders

Organs/Tissues associated with anti-ADRA2B antibody

 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >24 publications with ADRA2B and Heart
 Kidney Antibodies  >11 publications with ADRA2B and Kidney
 Nerve Antibodies  >4 publications with ADRA2B and Nerve
 Embryonic Tissue Antibodies  >3 publications with ADRA2B and Embryonic Tissue
 Ganglia Antibodies  >1 publications with ADRA2B and Ganglia
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000