Adrenomedullin (ADM) Antibody – Rabbit Polyclonal

The protein encoded by this gene is a preprohormone which is cleaved to form two biologically active peptides, adrenomedullin and proadrenomedullin N-terminal 20 peptide. Adrenomedullin is a 52 aa peptide with several functions, including vasodilation, regulation of hormone secretion, promotion of angiogenesis, and antimicrobial activity. The antimicrobial activity is antibacterial, as the peptide has been shown to kill E. coli and S. aureus at low concentration. [provided by RefSeq, Aug 2014]

ADM: AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels. Belongs to the adrenomedullin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 11p15.4

Cellular Component: cytoplasm; cytosol; extracellular region; extracellular space

Molecular Function: adrenomedullin receptor binding; hormone activity; protein binding; receptor binding

Biological Process: aging; androgen metabolic process; antibacterial humoral response; antifungal humoral response; blood circulation; cAMP biosynthetic process; cAMP-mediated signaling; cell-cell signaling; defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; developmental growth; elevation of cytosolic calcium ion concentration; female pregnancy; G-protein coupled receptor internalization; heart development; hormone secretion; negative regulation of cell proliferation; negative regulation of vascular permeability; negative regulation of vasoconstriction; neural tube closure; neurite regeneration; odontogenesis of dentine-containing teeth; organ regeneration; positive regulation of angiogenesis; positive regulation of apoptosis; positive regulation of cAMP biosynthetic process; positive regulation of cell proliferation; positive regulation of heart rate; positive regulation of vasodilation; progesterone biosynthetic process; receptor internalization; regulation of the force of heart contraction; response to cold; response to glucocorticoid stimulus; response to hypoxia; response to insulin stimulus; response to lipopolysaccharide; response to starvation; response to wounding; response to yeast; signal transduction; vasculogenesis