AGFG1 Antibody – Rabbit Polyclonal

The protein encoded by this gene is related to nucleoporins, a class of proteins that mediate nucleocytoplasmic transport. The encoded protein binds the activation domain of the human immunodeficiency virus Rev protein when Rev is assembled onto its RNA target, and is required for the nuclear export of Rev-directed RNAs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

RIP: Required for vesicle docking or fusion during acrosome biogenesis. May play a role in RNA trafficking or localization. In case of infection by HIV-1, acts as a cofactor for viral Rev and promotes movement of Rev-responsive element- containing RNAs from the nuclear periphery to the cytoplasm. This step is essential for HIV-1 replication. Interacts with EPS15R and EPS15. Interacts with FCHO1. Ubiquitously expressed. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear export; RNA-binding

Chromosomal Location of Human Ortholog: 2q36.3

Cellular Component: cell projection; cell soma; cytoplasmic membrane-bound vesicle; intracellular membrane-bound organelle; nuclear pore

Molecular Function: DNA binding; GTPase activator activity; metal ion binding; protein binding; RNA binding

Biological Process: acrosome formation; intermediate filament organization; mRNA export from nucleus; multicellular organismal development; positive regulation of GTPase activity; spermatid nuclear differentiation