AKAP1 Antibody – Rabbit Polyclonal

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to type I and type II regulatory subunits of PKA and anchors them to the mitochondrion. This protein is speculated to be involved in the cAMP-dependent signal transduction pathway and in directing RNA to a specific cellular compartment. [provided by RefSeq, Jul 2008]

AKAP1: Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. AKAP149 is highly expressed in prostate and small intestine whereas S-AKAP84 is expressed in kidney, pancreas, liver, lung and brain. AKAP149 is also expressed in colon carcinoma. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Mitochondrial; Adaptor/scaffold; RNA-binding; Membrane protein, integral

Chromosomal Location of Human Ortholog: 17q22

Cellular Component: cytosol; integral to membrane; lipid particle; membrane; mitochondrial crista; mitochondrial matrix; mitochondrial outer membrane; mitochondrion; neuromuscular junction; postsynaptic membrane

Molecular Function: beta-tubulin binding; microtubule binding; protein binding; protein complex scaffold; protein domain specific binding; protein kinase binding; protein phosphatase 2B binding; RNA binding

Biological Process: blood coagulation; negative regulation of NFAT protein import into nucleus; negative regulation of protein amino acid dephosphorylation