AKR1B1 Antibody – Rabbit Polyclonal

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database. [provided by RefSeq, Feb 2009]

AKR1B1: Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies. Belongs to the aldo/keto reductase family.

Protein type: Carbohydrate Metabolism - pyruvate; EC 1.1.1.21; Oxidoreductase; Carbohydrate Metabolism - pentose and glucuronate interconversions; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - fructose and mannose; Lipid Metabolism - glycerolipid

Chromosomal Location of Human Ortholog: 7q35

Cellular Component: cytoplasm; cytosol; extracellular space; mast cell granule; nucleoplasm; perinuclear region of cytoplasm

Molecular Function: aldehyde reductase activity; aldo-keto reductase activity; electron carrier activity; glyceraldehyde oxidoreductase activity

Biological Process: C21-steroid hormone biosynthetic process; carbohydrate metabolic process; fructose biosynthetic process; maternal process involved in pregnancy; naphthalene metabolic process; norepinephrine metabolic process; positive regulation of JAK-STAT cascade; positive regulation of smooth muscle cell proliferation; response to stress; response to water deprivation; sorbitol biosynthetic process; stress-activated protein kinase signaling pathway; tissue homeostasis