Albumin (ALB) Antibody – Mouse Monoclonal

Albumin is a soluble, monomeric protein which comprises about one-half of the blood serum protein. Albumin functions primarily as a carrier protein for steroids, fatty acids, and thyroid hormones and plays a role in stabilizing extracellular fluid volume. Albumin is a globular unglycosylated serum protein of molecular weight 65,000. Albumin is synthesized in the liver as preproalbumin which has an N-terminal peptide that is removed before the nascent protein is released from the rough endoplasmic reticulum. The product, proalbumin, is in turn cleaved in the Golgi vesicles to produce the secreted albumin. [provided by RefSeq, Jul 2008]

albumin: Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc. Plasma. Belongs to the ALB/AFP/VDB family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Carrier; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 4q13.3

Cellular Component: basement membrane; endoplasmic reticulum; extracellular region; extracellular space; Golgi apparatus; myelin sheath; nucleus; protein complex

Molecular Function: antioxidant activity; chaperone binding; copper ion binding; DNA binding; drug binding; enzyme binding; fatty acid binding; identical protein binding; oxygen binding; protein binding; pyridoxal phosphate binding; toxin binding; zinc ion binding

Biological Process: bile acid and bile salt transport; cellular response to starvation; hemolysis by symbiont of host red blood cells; lipoprotein metabolic process; maintenance of mitochondrion localization; negative regulation of apoptosis; negative regulation of programmed cell death; platelet degranulation; positive regulation of circadian sleep/wake cycle, non-REM sleep; receptor-mediated endocytosis; response to mercury ion; response to nutrient; response to organic substance; retinal homeostasis; sodium-independent organic anion transport; transport

Disease: Analbuminemia; Hyperthyroxinemia, Familial Dysalbuminemic