Angiotensinogen (AGT) Antibody – Rabbit Polyclonal

angiotensin: Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. In response to lowered blood pressure, the enzyme renin cleaves angiotensinogen to produce angiotensin-1 (angiotensin 1-10). Angiotensin-1 is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin-2 (angiotensin 1- 8). Angiotensin-1 and angiotensin-2 can be further processed to generate angiotensin-3 (angiotensin 2-8), angiotensin-4 (angiotensin 3-8). Angiotensin 1-7 is cleaved from angiotensin-2 by ACE2 or from angiotensin-1 by MME (neprilysin). Angiotensin 1-9 is cleaved from angiotensin-1 by ACE2. Genetic variations in AGT are a cause of susceptibility to essential hypertension (EHT). Essential hypertension is a condition in which blood pressure is consistently higher than normal with no identifiable cause. Defects in AGT are a cause of renal tubular dysgenesis (RTD). RTD is an autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype). Belongs to the serpin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1q42.2

Cellular Component: cytoplasm; extracellular region; extracellular space

Molecular Function: growth factor activity; hormone activity; protein binding; receptor agonist activity; serine-type endopeptidase inhibitor activity; sodium channel regulator activity; superoxide-generating NADPH oxidase activator activity; type 1 angiotensin receptor binding; type 2 angiotensin receptor binding

Biological Process: activation of NF-kappaB transcription factor; aging; angiotensin maturation; angiotensin mediated drinking behavior; angiotensin mediated regulation of renal output; artery smooth muscle contraction; blood vessel remodeling; cell surface receptor linked signal transduction; cell-cell signaling; cellular sodium ion homeostasis; cytokine secretion; female pregnancy; fibroblast proliferation; G-protein coupled receptor protein signaling pathway; G-protein signaling, coupled to cGMP nucleotide second messenger; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); kidney development; negative regulation of angiogenesis; negative regulation of cell growth; negative regulation of nerve growth factor receptor signaling pathway; negative regulation of tissue remodeling; nitric oxide mediated signal transduction; phospholipase C activation; positive regulation of blood pressure; positive regulation of cellular protein metabolic process; positive regulation of cytokine production; positive regulation of epidermal growth factor receptor signaling pathway; positive regulation of fibroblast proliferation; positive regulation of inflammatory response; positive regulation of NAD(P)H oxidase activity; positive regulation of nitric oxide biosynthetic process; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of superoxide release; positive regulation of transcription, DNA-dependent; positive regulation of vasodilation; regulation of blood pressure; regulation of calcium ion transport; regulation of cell growth; regulation of cell proliferation; regulation of heart rate; regulation of long-term neuronal synaptic plasticity; regulation of norepinephrine secretion; regulation of transmission of nerve impulse; regulation of vasoconstriction; renal system process; renin-angiotensin regulation of aldosterone production; renin-angiotensin regulation of blood vessel size; renin-angiotensin regulation of blood volume; response to muscle activity involved in regulation of muscle adaptation; smooth muscle cell proliferation; stress-activated MAPK cascade; vasodilation

Disease: Hypertension, Essential; Renal Tubular Dysgenesis