AP3D1 Antibody – Rabbit Polyclonal

The protein encoded by this gene is a subunit of the AP3 adaptor-like complex, which is not clathrin-associated, but is associated with the golgi region, as well as more peripheral structures. The AP-3 complex facilitates the budding of vesicles from the golgi membrane, and may be directly involved in trafficking to lysosomes. This subunit is implicated in intracellular biogenesis and trafficking of pigment granules, and possibly platelet dense granules and neurotransmitter vesicles. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

AP3D1: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. Belongs to the adaptor complexes large subunit family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: endosome membrane; Golgi apparatus; Golgi membrane; lysosomal membrane; membrane; membrane coat; nucleoplasm; terminal button

Molecular Function: transporter activity

Biological Process: anterograde axon cargo transport; anterograde synaptic vesicle transport; antigen processing and presentation, exogenous lipid antigen via MHC class Ib; eye pigment biosynthetic process; intracellular protein transport; melanosome organization and biogenesis; positive regulation of NK T cell differentiation; protein localization in organelle; synaptic vesicle membrane organization and biogenesis