APC Antibody – Rabbit Polyclonal

This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Jul 2008]

APC: a tumor suppressor. Defects in APC are a cause of familial adenomatous polyposis (FAP). Promotes rapid degradation of CTNNB1 and participates in Wnt signaling. Activity is correlated with its phosphorylation state. Two splice-variant isoforms have been described.

Protein type: Motility/polarity/chemotaxis; Tumor suppressor

Chromosomal Location of Human Ortholog: 5q21-q22

Cellular Component: beta-catenin destruction complex; catenin complex; cell cortex; cell soma; cell-cell adherens junction; centrosome; cytoplasm; cytoplasmic microtubule; cytosol; dendrite; kinetochore; lamellipodium; lateral plasma membrane; nuclear membrane; nucleoplasm; nucleus; plasma membrane; synapse; tight junction

Molecular Function: beta-catenin binding; cadherin binding; gamma-catenin binding; microtubule binding; microtubule plus-end binding; protein binding; protein kinase binding; protein kinase regulator activity

Biological Process: cell adhesion; cell cycle arrest; cell fate specification; cell migration; cell structure disassembly during apoptosis; cytokinesis after mitosis; establishment and/or maintenance of cell polarity; mitotic cell cycle spindle assembly checkpoint; negative regulation of cell proliferation; negative regulation of cyclin-dependent protein kinase activity; negative regulation of microtubule depolymerization; neurite development; pancreas development; pattern specification process; positive regulation of apoptosis; positive regulation of cell migration; positive regulation of protein catabolic process; positive regulation of pseudopodium formation; proteasomal ubiquitin-dependent protein catabolic process; protein complex assembly; regulation of attachment of spindle microtubules to kinetochore; regulation of cell differentiation; regulation of microtubule-based process; response to DNA damage stimulus; response to drug; Wnt receptor signaling pathway; Wnt receptor signaling pathway through beta-catenin

Disease: Colorectal Cancer; Desmoid Disease, Hereditary; Familial Adenomatous Polyposis 1; Gastric Cancer; Hepatocellular Carcinoma