ARCN1 Antibody – Rabbit Polyclonal

This gene maps in a region, which include the mixed lineage leukemia and Friend leukemia virus integration 1 genes, where multiple disease-associated chromosome translocations occur. It is an intracellular protein. Archain sequences are well conserved among eukaryotes and this protein may play a fundamental role in eukaryotic cell biology. It has similarities to heat shock proteins and clathrin-associated proteins, and may be involved in vesicle structure or trafficking. [provided by RefSeq, Jul 2008]

ARCN1: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.

Protein type: Vesicle

Chromosomal Location of Human Ortholog: 11q23.3

Cellular Component: COPI vesicle coat; cytoplasm; cytosol; endoplasmic reticulum membrane; Golgi apparatus; Golgi membrane; intracellular membrane-bound organelle; membrane; transport vesicle

Biological Process: adult locomotory behavior; cerebellar Purkinje cell layer maturation; ER to Golgi vesicle-mediated transport; intracellular protein transport; pigmentation; retrograde vesicle-mediated transport, Golgi to ER